The Cell Cycle
Cells reproduce through a continuous sequence 2 main stages; growth and division
The first and longest stage is interphase
G1: cells carry out metabolic process to prepare for the S phase
S: DNA replication occurs, cells can enter either the S phase or a rest phase from G1
G2: cells prepare to undergo cell division
Then mitosis and cell division
DNA Structure
made up of 2 long strands that form a spiral shape called double helix
Dna exists as strand of chromatin fiber
Individual strands of DNA is called a nucleotide
They are made up of phosphate group, a sugar group and a base
Adenine (A), Guanine (G), Thymine (T), Cytosine ©
A-t and g-c and these are called complementary pairs
The complete DNA Structure in every cell organism is called genome
Single chromosome is comprised of 2 sister chromatids and are held together by a centromere
Sister chromatids are genetic copies of each othe
Mitosis defintion
In order for an organisms to replicate, grow or repair new cells are needed
The division of the cell nucleus where daughter cells receive the exact number of chromosomes and genetic makeup as the parent cells
46 chromosomes are produced
mitosis prophase
chromatin condenses and thickens for form visible duplicated chromosomes
Centrioles begin to migrate to opposite poles of the cells
Spindle fibers begin to form between the two centrioles
mitosis metaphase
Chromosomes migrate and align themselves at the middle of the cell
Centrioles arrive at opposite poles, spindle fibers are connected
Sister chromatids are attached to opposite spindle fibers
mitosis anaphase
centromeres split and the sister chromatids are pulled to opposite poles of the spindle fibers
spindle fibers shorten which allow pulling action to occur
mitosis telophase
mitosis is complete and 2 daughter cells are formed
Chromatids reach opposite poles triggering telophase
Each chromatid is now a single chromosome
Nuclear membrane reappears
meiosis prophase 1
homologous chromosomes pair up forming a tetrad which consists of 4 chromatids
Crossing over occurs
meiosis metaphase 1
tetrads randomly align themselves along the cell equator and they line up in pairs, it's called independent assortment
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meiosis anaphase 1
homologous pairs separate and move to opposite poles with sister chromatids remaining together therefore 1 chromosome from each pair
meiosis telophase 1
daughter cells are formed with each daughter cell containing only one chromosome of the homologous pair
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meiosis prophase 2
chromosomes condense and the nuclear envelope breaks down if needed, centrosomes move apart and the spindle fibers form between them
meiosis metaphase 2
chromosomes line up individually along the equator (still in x)
meiosis anaphase 2
sister chromatids separate and are pulled towards opposite poles of the cell
meiosis telophase 2
nuclear membrane form around each set of chromosomes and the chromosomes decondense
Four haploid cells
mitosis mutation
Mutations: An error in the DNA sequence that can be caused by toxic compounds, radiation and or virus
Tumors can be an example
The mutations are usually copied during prophase therefore passing the mutation to the daughter cell
Genes that can be activated by mutations are called oncogenes
meiosis muatation
Failure to separate chromosomes is called nondisjunction
Monosomy: one less chromone (45)
trisomy ; one extra chromosome (46)
Iversion
occurs when a certain gene segment becomes free momentarily and is reinserted in the reverse order
Translocation
part of chromosome change places with another part of the same chromosome or with part of another non-homologous chromosome; can be linked to cancer
Deletion
a portion of the chromosome is actually lost. Genes are lost from the chromosome. Caused by virus, chemicals and irradiation
Duplication
when a gene sequence is repeated one or more times one or several chromosomes
Monohybrid cross
a cross between 2 individuals in which only one trait is crossed
Genotype
the genetic makeup of an organism
Phenotype
the physical appearance of an organism
Dihybrid cross
a cross between two individuals focusing on two specific traits
Test cross
If you have an individual with a particular phenotype but whose genotype is unknown we need to perform a test cross
pedigrees
A chart that shows the pattern of inheritance over many generations
Incomplete dominance:
an inheritance pattern where the heterozygous exhibits an intermediate phenotype (blend). Neither allele for trait is completely dominant
Codominance
a circumstance in which both alleles for a trait are dominant. Both alleles are expressed in hetero
Multiple alleles:
a pattern of inheritance where a gene may have more than two alleles for any given trait
Sex-Linked Inheritance
Some traits that are passed from one generation to the next depend on the sex of the parent carrying the trait. The transmission of genes which are located on the X or Y chromosome is called ….