Acute Exam 4

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Manifestations of renal insufficiency

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Iggy Chapter 60, 63, 53, 54, 51, 52, 55 (pp. 204-1209)

69 Terms

1

Manifestations of renal insufficiency

  • decreased urine output

  • fluid retention

  • edema in the lower extremities

  • shortness of breath

  • fatigue

  • proteinuria

  • disturbances in fluid and electrolyte balance

  • disturbances in acid-base balance

  • buildup of nitrogen based waste in the urine

  • loss of kidney hormone function

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Regulatory functions of the kidney

Glomerular filtration- first process in urine formation, filters blood and pulls water, electrolytes, and small particles

  • kidneys self regulate their blood pressure and blood flow so this is constant

  • increased or decreased depending on blood pressure and blood flow

Tubular reabsorption- second process in urine formation, most water, electrolytes, and small particles are returned to the blood

  • kidneys vary the volume or concentration of urine to help regulate fluid and electrolyte balance regardless of fluid intake

Tubular secretion- third process or urine formation, allows substances to move from the blood into the urine

  • potassium and hydrogen ions are moved from the blood to the urine to maintain fluid and electrolyte balance and acid-base balance

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Hormonal functions of the kidney

Renin- assists in blood pressure control

  • released when there is a decrease in blood flow, blood volume, or blood pressure through the renal arterioles, or there is too little sodium in kidney blood

  • causes the production of angiotensin II which increases systemic blood pressure

  • when blood flow to the kidney is reduced, it prevents fluid loss and maintains circulating blood volume

Prostaglandins- help regulate glomerular filtration, kidney vascular resistance, and renin production

  • increase sodium and water excretion

Erythropoietin- produced and released in response to decreased oxygen in the kidney’s blood supply

  • triggers RBC production in the bone marrow

Vitamin D- converted to active form in the kidneys

  • activated vitamin D is needed to absorb calcium and regulate calcium balance

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4

CT scans purpose

  • to measure kidney size

  • to evaluate contour to assess for injury, masses, or obstruction in kidneys or the urinary tract

  • assess renal blood flow

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5

Concerns with using contrast dye with CT scans

  • when contrast is used, ensure that there is sufficient oral or IV intake to dilute and excrete the contrast media

  • it is potentially kidney damaging (nephrotoxic)

    • highest risk for older adults, dehydration, pre-existing CKD, diabetes, heart failure, current hypotension

    • those taking metformin should be temporarily discontinued before receiving contrast

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6

Bladder scans

  • noninvasive method of estimating bladder volume

  • used to screen for postvoid residual volumes

  • determine the need for intermittent catheterization

  • before scanning select male or female icon

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Laboratory tests and kidney function

  • serum creatinine- no other condition besides kidney disease increases this, creatinine is excreted solely by the kidneys

  • blood urea nitrogen (BUN)- kidneys filter this so if it is high it may indicate kidney disease

  • glomerular filtration rate (GFR)

  • color of urine

  • odor of urine

  • specific gravity

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Peritoneal dialysis

  • allows exchange of wastes, fluid, and electrolytes to occur in the peritoneal cavity

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Complications of peritoneal dialysis

  • peritonitis (connection site contamination)

  • pain

  • exit site and tunnel infections

  • fibrin clot formation

  • dialysate leakage

  • bleeding

  • bowel perforation

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Hemodialysis

  • removes excess fluids and waste products and restores fluid and electrolyte and acid-base balance

  • involves passing the patient’s blood through an artificial semipermeable membrane to perform the kidney’s filtering and excretion function

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Complications of hemodialysis

  • hypotension

  • dialysis disequilibrium syndrome

  • cardiac events

  • reaction to dialyzers

  • access complications (thrombosis, stenosis, infection)

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12

Appendicitis

  • an acute inflammation of the vermiform appendix that occurs most often among young adults

  • condition where the appendix becomes inflamed and filled with pus

  • occurs when the lumen (opening) of the appendix is obstructed which leads to infection as bacteria invades the walls of the appendix

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Appendicitis cause

  • initial obstruction is usually a result of very hard pieces of feces

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Appendicitis symptoms

  • rebound tenderness in the lower right abdominal quadrant

  • nausea

  • vomiting

  • poor appetite

  • fever

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Appendicitis treatment

  • appendectomy

  • antibiotics

  • if untreated can lead to infection (peritonitis) and systemic complications

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Ulcerative colitis

  • widespread chronic inflammation of the rectum and rectosigmoid colon but can extend to the entire colon

  • periodic remissions and exacerbations

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Ulcerative colitis symptoms

  • bloody and mucusy stool

  • tenesmus

  • lower abdominal and colicky pain relieved with defecation

  • malaise

  • anorexia

  • anemia

  • dehydration

  • fever

  • weight loss

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Ulcerative Colitis treatments

  • drug therapy- aminosalicylates, glucocorticoids, antidiarrheal drugs, immunomodulators

  • may be kept NPO to ensure bowel rest

  • TPN

  • nutrition therapy

  • surgical management for complications of UC

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Crohn’s disease

  • a chronic disease that presents inflammation in the digestive tract that causes thickened bowel walls

  • can affect any part of the GI tract mouth to anus but usually affects the small intestine and the beginning of the large intestine

  • recurrent with remissions and exacerbations

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Crohn’s Disease symptoms

  • diarrhea

  • abdominal pain

  • low grade fever

  • weight loss

  • anemia

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Treatments for Crohn’s disease

  • anti-inflammatory medications-NSAIDs

  • steroids

  • immunosuppressive drugs

  • vitamins

  • antibiotics

  • Surgery- bowel resections

  • self care- dietary fiber

  • enemas

  • TPN

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Colorectal cancer

  • cancer of the large intestine

  • highly curable, especially if diagnosed early

  • major risk factors- older than 50, genetic predisposition, family history of cancer

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Screening for colorectal cancer

  • starts at 45

  • colonoscopy every 10 years

  • people who have a personal or family history will have screening beginning earlier and more frequently

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Polyps

  • small growths covered with mucosa and attached to the surface of the intestine

  • most are benign

  • significant because some have the potential to become malignant

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Treatment for colorectal cancer

  • radiation

  • chemotherapy

  • colon resection

  • colectomy

  • colostomy

  • abdominoperineal resection

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Peritonitis

  • life threatening acute infalmmation and infection of the visceral/parietal peritoneum and endothelial lining of the abdominal cavity

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Peritonitis cause

  • contamination of the peritoneal cavity by bacteria or chemicals

  • perforation- appendicitis, diverticulitis, peptic ulcer disease

  • external penetrating wound

  • gangrenous gallbladder or bowel segment

  • bowel obstruction

  • ascending infection through the genital tract

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Peritonitis symptoms

  • rigid, board-like abdomen

  • abdominal pain

  • distended abdomen

  • nausea, anorexia, vomiting

  • diminishing bowel sounds

  • inability to pass flatus or feces

  • rebound tenderness in the abdomen

  • high fever

  • tachycardia

  • dehydration from high fever

  • decreased urine output

  • hiccups

  • possible compromise in respiratory status

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Peritonitis treatment

  • broad spectrum antibiotics

  • abdominal surgery may be needed to identify and repair the cause

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Enteral feedings

  • tube feeding

  • via NET, NG tube, or NDT

  • PEG

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Why are enteral feedings prescribed

If a patient cannot achieve adequate nutrition via oral intake

  • those who can eat but cannot maintain adequate nutrition by oral intake of food alone (older adults or patients receiving cancer treatment)

  • those with permanent neuromuscular impairment who cannot swallow (brain attack, severe head trauma, advanced MS)

  • those who do not have permanent neuromuscular impairment but cannot eat because of their condition

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32

Concerns with enteral feedings

  • refeeding syndrome

  • tube misplacement and dislodgment

  • abdominal distension and nausea/vomiting- caused by overfeeding

  • fluid and electrolyte imbalances

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TPN

  • this form of nutrition is introduced into the veins

  • administered with an infusion pump

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Care of central line with TPN

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35

Diabetes and kidney failure

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36

AV fistula

  • an internal anastomosis of an artery to a vein

  • do not take blood pressure on this arm

  • takes 2-3 months to form

  • is used for hemodialysis

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37

AV graft

  • looped plastic tubing tunneled beneath the skin, connecting, an artery and a vein

  • do not take blood pressure on this arm

  • takes 1-3 weeks to be ready

  • used for hemodialysis

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38

IJ catheter

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39

Chronic kidney disease

  • progressive, irreversible disorder, lasting more than 3 months

  • when kidney function and waste elimination are too poor to sustain life, CKD becomes end-stage kidney disease (ESKD)

  • different stages based on GFR

  • affects all body systems

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40

CKD fluid restriction

  • patient is at risk for fluid overload

  • ability to produce diluted urine is reduced

  • urine output decreases

  • extracellular volume can occur because the body loses the ability to secrete sodium

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41

CKD sodium restriction

  • in the later stages, kidney excretion of sodium is reduced as urine production decreases

  • it only takes a small increase in dietary sodium to get hypernatremia because they do not have the ability to excrete it from their body

  • sodium can seem falsely low because water is also being retained (dilution)

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42

Cystoscopy

  • to identify abnormalities of the bladder wall and urethral and ureteral occlusions

  • to treat small obstructions of lesions via fulguration, lithotripsy, or removal with a stone basket

  • an endoscopy scope is inserted through the urethra into the bladder, urethra, and lower portions of the ureters

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43

Concerns post-procedure for cystoscopy

  • monitor for airway patency and breathing, changes in vital signs, changes in urine output, excessive bleeding, and infection

  • observe for the complications of bladder puncture (severe pain, nausea, and vomiting)

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44

Acute Kidney injury

  • when kidney function decline is sudden and results in failure to maintain waste elimination, fluid and electrolyte balance, and acid-base balance

  • occurs over a few hours or days

  • can be a temporary condition that resolves or can progress to CKD

  • affects many body systems, but not all

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45

AKI causes

  • reduced perfusion to the kidneys (blood or fluid loss, heart attack, sepsis, severe dehydration)

  • damage to kidney tissue (glomerulonephritis, lupus, blood clot in nearby veins and arteries)

  • obstruction of urine outflow (bladder cancer, cervical cancer, prostate cancer, kidney stones)

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46

Indicators of Acute Kidney Injury

  • increase of serum creatinine within 48 hours

  • urine volume of less than 0.5/ml/hr for 6 hours

  • decreased GFR (is not a good indicator because it can me impacted by many factors)

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47

Indicators of Chronic Renal Failure

  • symptoms from every body system

  • extreme changes in…

    • creatinine

    • BUN

    • sodium

    • potassium

    • calcium

    • phosphorous

    • bicarbonate

    • hemoglobin

    • hematocrit

    • GFR

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48

Cirrhosis

  • widespread fibrotic (scarred) bands of connective tissue that change the liver’s anatomy and physiology

  • in early disease the liver is enlarged and firm

  • in later disease the liver shrinks and becomes harder

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49

Complications of Cirrhosis

  • Portal hypertension- persistent increase in pressure within the portal vein that happens due to obstruction or increased resistance of blood flow

  • Ascites- collection of free fluid within the peritoneal cavity caused by increased hydrostatic pressure from portal hypertension

  • Esophageal varices- when fragile, thin walled esophageal veins become distended and torturous from increased pressure

  • Biliary obstruction

  • Hepatic encephalopathy- complex cognitive syndrome that results from liver failure and cirrhosis

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50

Causes of Cirrhosis

  • chronic alcoholism

  • chronic viral hepatitis

  • bile duct disease

  • hepatitis C

  • hepatitis B

  • hepatitis D

  • nonalcoholic fatty liver disease

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Signs and symptoms of Cirrhosis

Early

  • fatigue

  • significant change in weight

  • GI symptoms (anorexia, vomiting)

  • pain in the abdominal area and liver tenderness

Late

  • GI bleeding

  • jaundice

  • ascites

  • spontaneous bruising

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52

Hepatitis A cause

  • RNA virus that can be killed by bleach

  • spread via fecal-oral route by fecal contamination

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53

Hepatitis B cause

Spread through…

  • unprotected sex

  • sharing needles

  • blood transfusions

  • direct contact with infected blood

  • birth

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54

Hepatitis C cause

  • RNA virus

Spread through

  • transmission is blood to blood

  • illicit IV drug needle sharing

  • blood, blood products, or organ transplant before 1992

  • hemodialysis

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Hepatitis D cause

  • defective RNA virus

  • occurs only with hepatitis B

  • transmitted primarily by parenteral routes, mostly IV drug users or unprotected sex

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Hepatitis E cause

  • waterborne infection

  • caused by fecal contamination of food and water

  • not common in the US

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Fatty liver disease

  • associated with aging, obesity, diabetes type II, and metabolic syndrome

  • can progress to liver cancer, cirrhosis, or failure

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58

Cholecystitis

  • inflammation of the gallbladder

  • can be acute or chronic

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59

Cholecystitis symptoms

  • episodic or vague upper abdominal pain or discomfort that can radiate to the right shoulder

  • pain triggered by a high-fat or high-volume meal

  • anorexia

  • nausea and/or vomiting

  • dyspepsia

  • eructation

  • flatulence

  • feeling of abdominal fullness

  • rebound tenderness

  • fever

  • jaundice, clay colored stools, dark urine

  • steatorrhea

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Causes of Cholecystitis

  • calculous- chemical irritation and inflammation from gallstones that obstruct the cystic duct, gallbladder neck, or common bile duct

  • acalculous- associated with biliary stasis caused by any condition that affects the regular filling or emptying of the gallbladder

  • chronic- repeated episodes of cystic duct obstruction cause chronic inflammation

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Treatment of Cholecystitis

  • treating the pain

  • extracorporeal shock wave lithotripsy- breaks up large stones

  • percutaneous transhepatic biliary catheter- opens blocked duct so bile can flow

  • cholecystectomy- surgical removal of the gallbladder

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Causes of Pancreatitis

  • premature activation of excessive pancreatic enzymes that destroy ductal tissue and pancreatic cells, resulting in autodigestion and fibrosis of the pancreas

  • trauma

  • pancreatic obstruction (tumor, cysts, absecesses)

  • metabolic problems (hyperlipidemia, hyperparathyroidism, hypercalcemia)

  • alcoholism

  • toxicities of drugs

  • cigarette smoking and tobacco use

  • CF

  • gallstones

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Treatment of Pancreatitis

  • hydration with IV fluids

  • pain control

  • drug therapy

  • withhold food and fluids (NPO)

  • surgical management is not usually indicated

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Complications of Pancreatitis

  • pancreatic infections

  • hemorrhage

  • acute kidney failure

  • paralytic ileus

  • hypovolemic shock

  • pleural effusion

  • acute respiratory distress syndrome

  • atelectasis

  • pneumonia

  • multiorgan system failure

  • DIC

  • Type II diabetes

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Intestinal Obstructions

  • mechanical obstruction

  • nonmechanical obstruction

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Different Types of hernias

  • indirect inguinal hernia

  • direct inguinal hernia

  • femoral hernia

  • umbilical hernia

  • incisional or ventral hernia

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Treatment for different types of hernias

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68

Different types of IBS

IBS D- diarrhea

IBS C- constipation

IBS A- alternating diarrhea and constipation

IBS M- mix of diarrhea and constipation

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Treatment for different types of IBS

IBS D- antidiarrheal agents

IBS C- bulk forming laxatives

IBS A-

IBS M

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