Population Genetics Pt. B

A region in which genetically distinct parapatric populations (often species) interbreed. Because they’re right next to each other.

Gradual change in a character or allele frequencies over a geographic distance- often indicative of adaptive geographic variation.

Populations that don’t overlap, and are often separated by a distance.

Populations that overlap each other

Populations that don’t overlap, but are just adjacent to each other (not separated by a distance.

POTENTIAL CONSEQUENCE OF HYBRIDIZATION

Hybrids that are less fit than either purebred species. The species continue to diverge until hybridization can no longer occur.

POTENTIAL CONSEQUENCE OF HYBRIDIZATION

Reproductive barriers weaken until the two species become one.

POTENTIAL CONSEQUENCE OF HYBRIDIZATION

Fit hybrids continue to be produced.

The process in which two complementary single-stranded DNA and/or RNA molecules bond together to form a double-stranded molecule.

Assuming the population is large, and no selection (neutral) on new mutations.

A mutation from A to a. Rate is u

Assuming the population is large, and no selection (neutral) on new mutations.

A mutation from a to A. Rate is v

Random fluctuations in the frequencies of alleles or haplotypes, often leading to some alleles being fixed (100% frequency). It is a form of nonadaptive evolution, consequence of chance.

Smaller the population, bigger the effect.

A circumstance that decreases the size of a population.

A special type of bottleneck in which a small number of individuals establishes a new population. The new population will experience genetic drift because of small population size, and may lose some rare alleles from the original population.

Smaller the founder bottleneck, the faster heterozygosity decreases

After numerous generations, the population size increases, and mutation and recombination restore heterozygosity.

Condition of having two different alleles at a locus.

General indicator of the amount of genetic variability.

Concept that all gene copies in a population are derived from a common ancestor.

The smaller the population, the less time required for coalescence.

IMPORTANT: By chance, a FINITE pop (violation of HW) will eventually become monomorphic for one allele. The probability of a neutral allele (no selective advantage to phenotype) becoming fixed is equal to its initial frequency.

DNA markers that cannot be used to differentiate between or among phenotypes.

If in the population only one allele occurs at a site or locus, we shall say it is monomorphic in that population.

If the jaguar has only one possible trait for that gene, it would be termed “monomorphic.”

Small independent populations of a species.

Several proximate demes

Equally likely consecutive changes that result in fixation or loss of an allele.

Some demes will either lose or become fixed for an allele- this probability increases with time.

1. Allele or haplotype frequencies fluctuate randomly in a deme, and eventually one allele or haplotype will become fixed.

2. Due to #1, genetic variation at a locus declines with time, the frequency of heterozygotes [H=2p(1-p)] declines, and this decline can be a proxy for genetic drift in the population.

3. An allele’s probability of becoming fixed equals its frequency at that time, regardless of past changes in its frequency.

4. Demes (populations) with the same initial allele frequency (p) undergo random walk, where a proportion (p) will become fixed for one form of the allele, and a proportion of others (1-p) become fixed for the alternate allele.

5. The frequency of a new mutation that is represented by one gene copy in a population with 2N gene copies is:

   1. pt= ½ N= probability of p becoming fixed

NOTICE AS POPULATION SIZE (N) INCREASES, pt DECREASES

6. As seen in #5, genetic drift occurs faster in smaller populations. In a diploid population, the average time to fixation of a new, neutral mutant allele (assuming it becomes fixed) is 4N generations.

7. Among demes in a metapopulation, the average allele frequency (p) changes little (small number of demes) or not at all (large number of demes), but as allele frequencies in each deme become 0 or 1 over time, the frequency of heterozygotes (H) declines to 0 in each deme, AND in the metapopulation as a whole.

Actual number of adults in a population

Number of individuals in an ideal population (where every adult mates) in which the rate of genetic drift (measured by decline in heterozygosity) would be the same as it is in the actual population.

E.G: 10,000 adults, but only 1,000 breed, then genetic drift proceeds at same rate as a population of 1,000 (Ne).

Genetic drift and loss of heterozygosity increase.

Bad bc it can lead to decreased viability and/or inbreeding depression.

1. Variation in the offspring produced by females, males, or both

2. Sex ratio that differs from 1:1

3. Natural selection increases variation in offspring of certain phenotypes

4. If generations overlap, probability of inbreeding increases

5. Fluctuations in population size, especially when population sizes are small

The reduction of fitness (survival and/or reproductive output) resulting from an increase in deleterious homozygous recessive alleles in inbred individuals- big problem with endangered species captive breeding programs

Introduction of new genes to inbred population

Descended from the same copy in a common ancestor.

Same in structure in function, but are descended from two dif. copies in ancestors.

Measure of probability of two alleles being identical by descent. Ranges from 0 (random mating) to 1 (all alleles identical by descent)

• f(AA)= p²+Fqp

• f(Aa)= 2pq-2Fpq

• f(aa)= q²+Fpq

When inbreeding is occurring, heterozygote proportion decreases by 2Fpq, and half of this value is added to the proportion of each homozygote.

Self- Reduces heterozygotes by half each generation. Completely homozygous population

Siblings- Increases % of homozygotes relative to random mating

First cousins- Increases % of homozygotes, but at a slower rate

As (N) increases, genetic drift has less of an effect.

Whereas mutation rate has more of an effect.

Heterozygosity increases with mutation rate and population size.

Measures variation in a locus for two alleles among populations- ranges from 0 (no variation- lots of gene flow) to 1 (populations fixed for dif. alleles- no gene flow)

EVEN A LITTLE GENE FLOW KEEPS HETEROZYGOSITY HIGH