what are stem cells?
a type of cell that can differentiate into many different types of cells
what is meant by the term undifferentiated?
they are unspecialised and so are not adapted to any particular function
what problem can the division of stem cells cause if too slow?
tissues not efficiently replaced leading to aging
what problem can the division of stem cells cause if too fast or too much?
can form tumours which can lead to the development of cancer
what is meant by potency?
a stem cell’s ability to differentiate into different cell types
what is meant by totipotent?
stem cells that can differentiate into any type of cell
what is meant by pluripotent?
stem cells that can form any tissue type but not whole organisms
what is meant by multipotent?
stem cells that can only form a range of cells within a certain type of tissue
what is the benefit of being a multicellular organism?
groups of cells working together as one unit can make use of resources more efficiently than single cells
how are blood cells an example of the benefit of being a multicellular organism?
they look very different to other cells as they are adapted to their function, white blood cells can fight off pathogens and at the same time red blood cells can supply oxygen to respiring tissues
why do blood cells need to be produced from stem cells? and where are stem cells located?
they have a short life span of around 120 days so need to be replaced consistently, located in the bone marrow
how long do neutrophils live and how many do stem cells reproduce an hour?
they live about 6 hours and stem cells produce around 1.6 billion per kg per hour
what are the two main sources of animal stem cells?
embryonic stem cells and tissue (adult) stem cells
what potency are the two types of animal stem cells at?
embryonic- totipotent but pluripotent once blastocyst (mass of cells) is formed after a few days
tissue- multipotent
how are the two types of adult stem cells recovered?
embryonic- early stage of embryo development
tissue- bone marrow or umbilical cord
where are stem cells found in plants?
in the meristem tissue which is found where growth is occurring e.g., tips of roots and shoots
what potency are plant stem cells at?
pluripotent
what is the normal function of stem cells in plants?
vascular cambium, growth of plant as the vascular tissue grows as the plant grows, form xylem and phloem cells
what diseases can stem cells help treat?
heart disease, type 1 diabetes, parkinsons, alzheimers, birth defects, spinal injuries
what injury can stem cells treat?
burns- new skin can be grown from stem cells
how are stem cells helpful to drug trials?
new drugs can be tested on cultures of stem cells rather before animals
how are stem cells helpful to developmental biology?
they can be used to study the changes as multicellular organisms grow
what are the main objections to using stem cells for research?
religious and moral belief that life starts at conception and so when the cell is destructed during harvesting it is murder, rights of ownership
what are the issues with using stem cells from umbilical cords?
only multipotent cells which restricts their usefulness
how are erthrocytes specialised?
very small, have large SA to V ratio increased by the biconcave shape means oxygen can easily diffuse across their membranes
flexible due to well developed cytoskeleton, allows them to change shape so they can twist and turn as they travel through very narrow capillaries
most organelles lost at differentiation provides more space for haemoglobin molecules
how are spermatozoa specialised?
many mitochondria to provide lots of ATP for the tail to move and propel the cell
small but long and thin so they can move easily
has an acrosome (special type of lysosome) which releases enzymes to digest outer covering of ovum
how are neutrophils specialised?
flexible shape which can mold to the shape of its target
twice the size of erythrocytes so they can ingest pathogens
how are epithelial cells specialised?
many have cilia which are used to waft substances in one direction
squamous epithelial cells are flattened in shape and form a thin cross-section which shortens the diffusion pathway and is permeable
how are palisade cells specialised?
long and cylindrical, pack together quite closely with little space between them for air to circulate, co2 in the air spaces diffuse into cells
large vacuole so that chloroplasts are positioned near the periphery of the cell reducing diffusion distance for co2
contain many chloroplasts for photosynthesis
contain cytoskeleton threads and motor proteins to move the chloroplasts up or down the leaf depending on light intensity
how are guard cells specialised?
they use light energy to produce ATP in order to actively transport potassium ions from the surrounding epidermal cells into the guard cells, lowering their water potential
when water enters via osmosis they swell causing the stomata to enlarge, they are now open and gaseous exchange can occur so co2 can enter the palisade cells for photosynthesis
oxygen can also diffuse out when stomata are open, when the plant doesnt want anything to diffuse out the guard cells lose water and become flaccid closing the stomata
how are root hair cells specialised?
hair like projection increases surface area for absorption of water and mineral ions from the soil into which it projects
special carrier proteins in the plasma membranes in order to actively transport mineral ions in
produce ATP required for active transport
as the mineral ions actively transport in, it lowers the water potential allowing water to enter via osmosis
how is epidermal tissue specialised?
consists of flattened cells which form a protective covering over leaves, stems and roots
some have walls impregnated with a waxy substance forming a cuticle to prevent water loss from the plant
how is vascular tissue specialised?
xylem vessels carry water and minerals from roots to all parts of the plant
phloem sieve tubes transfer products of photosynthesis from leaves to other parts of the plant that don’t photosynthesise
how is meristematic tissue specialised?
can divide by mitosis and differentiate into other types of cells
how are xylem vessels specialised? (vascular cambium)
lignin is deposited into the meristematic cells cell walls to reinforce and water proof them, this does kill them
the ends of the cell breaks down so that the xylem forms continuous columns with wide lumens to carry water and dissolved minerals
how are phloem sieve tubes specialised? (vascular cambium)
sieve tubes lose most of their organelles and sieve plates develop between them
how are companion cells specialised? (vascular cambium)
companion cells retain their organelles and continue metabolic functions to provide ATP for active loading of sugars into the sieve tubes
how is epithelial tissue specialised?
have short cell cycles so can divide up to 2 or 3 times a day to replace worn or damaged tissue
no blood vessels receive nutrients via diffusion so have a very thin cross section to shorten diffusion pathway
how is connective tissue specialised?
the matrix within the cells separates the living cells within the tissue enabling it to withstand forces such as weight
how are muscle cells specialised?
muscle cells are called fibres that are elongated and contain special organelles called myofilaments which allow the muscle tissue to contract