Module 16: Drugs Acting on the Gastrointestinal System (Part I)

Peristalsis, an involuntary movement that delivers food from the mouth to the stomach is controlled by the __.

How many liters of gastric content can the stomach hold?

What is the average emptying time?

True or False: Solids and fats both take longer to digest.

What cells produce pepsinogen, an inactivated enzyme?

What cells produce hydrochloric acid, activating pepsinogen to pepsin?

What cells secrete a substance that stimulates hydrochloric acid to convert pepsinogen to pepsin?

What cells produce a substance that protects the stomach wall from the acid and digestive enzymes from the stomach?

What is the location of most drug absorption?

True or False: All drugs, even those that are soluble in alcohol or lipid, are mostly absorbed in the small intestine.

What are the three parts of the small intestine?

What substance produced by the small intestine suppresses gastric secretion but increases gastric juice pH, regulates gastric acid and pancreatic bicarbonate, and is responsible for osmoregulation?

What substance produced by the small intestine stimulates the pancreas to release enzymes that allow the gallbladder to contract, releasing bile into the duodenum?

What is the location of most water absorption?

What disease develops due to an imbalance between defensive and aggressive factors, often causing an erosion of the lining of the stomach accompanied by circumscribed lesions and burning pain?

Infections with __ is the most common cause of peptic ulcers.

When does the gnawing, burning pain associated with peptic ulcers often occur?

True or False: Antibiotics for H. pylori infections do not alter the disease process and instead create conditions that are conducive to healing.

What disease is characterized by epigastric pains 30 minutes to 1 hour after meals, increasing in intensity during meals, with no pain at hours of sleep, and is relieved by vomiting?

What may occur when a patient experiences gastric ulcers?

What disease is characterized by epigastric pains 2-3 hours after meals, decreasing in intensity during meals, and with pain during hours of sleep?

What may occur when a patient experiences duodenal ulcers?

These fast-acting but short-duration drugs neutralize gastric acid when ingested.

What drugs should one avoid taking with antacids to prevent the inactivation of medication?

What systemic antacid is the first to relieve heartburn, sour stomach/acid indigestion, and stomach/duodenal ulcers but is seldom used for acid neutralization due to its side effects?

What systemic antacid is the most effective in neutralizing acid?

This is intensified when calcium carbonate is taken with milk.

What non-systemic antacid neutralizes gastric pH by neutralizing hydrochloric acid?

What is a common side effect of taking aluminum hydroxide?

Long-term use of aluminum hydroxide may lead to what three effects?

A patient who was prescribed Aluminum hydroxide arrives at the clinic complaining of white streaks in her stool. Is this normal or abnormal?