Pharm Ana 12 - Tablets

most common type of pill

T or F

The general appearance of a tablet, its identity, and general elegance is essential for consumer acceptance, for control of lot-to-lot uniformity and tablet-to-tablet uniformity.

The control of general appearance involves the measurement of the following:

• It can be dimensionally described & controlled.
• The thickness of a tablet is only variables.
• Tablet thickness can be measured by micrometer or by another device.
• Tablet thickness should be controlled within a ± 5% variation of standard value.

It is used to measure tablet thickness

Tablet thickness should be controlled within a ___% variation of standard value

Common Tablet Shapes

• These markings utilize some form of embossing, engraving or printing.
• These markings include company name or symbol, product code, product name etc.

Common Tablet Profiles

The principles of ADME

A in ADME

D in ADME

M in ADME

E in ADME

prevents tablet from opening in stomach at low pH (acidic)

Enteric coat dissolves at ________ pH in the _________ (organ).

After enteric coat is dissolved in the small intestine, what substances are released?

API is absorbed acrros intestinal wall via ____________ (transport).

it orally delivers intact, biologically active API into systemic circulation

T or F

Efficacy has been demonstrated for peptides and small molecules varying in size, charge, hydrophobicity, stability and therapeutic indications.

• Color distribution must be uniform with no mottling.
• For visual color comparison compare the color of sample against standard color.
• The presence of odor in a batch of tablet indicates a stability problem such as the characteristics odor of acetic acid in an aspirin tablet.
• The presence of odor could be characteristic of the drug (Vitamin), added ingredients (flavoring agent) or the dosage form (film-coated tablet have a characteristic odor).
• For chewable tablet presence or absence of specified taste can be checked.
• A tablet level of flaws such s chip, cracks, contamination from foreign solid substances (hair, drops of oil, dirt), surface texture (smooth vs rough) and appearance (shining vs dull) may have zero defect

T or F

Color distribution must be uniform with no mottling.

T or F

For visual color comparison compare the color of sample against standard color.

The presence of odor in a batch of tablet indicates a _____________ such as the characteristics odor of acetic acid in an aspirin tablet.

The presence of odor could be characteristic of the?

T or F

For chewable tablet presence or absence of specified taste can be checked.

T or F

A tablet level of flaws such as chip, cracks, contamination from foreign solid substances (hair, drops of oil, dirt), surface texture (smooth vs rough) and appearance (shining vs dull) may have zero defect

T or F

Tablets will take its pharmacological effect after passing and absorbing through the small intestine.

the coat gets degraded first before the API of the drug

is equal to the total of the filtration rates of the functioning nephrons in the kidney. GFR is considered the optimal way to measure kidney function,