AP Bio: Unit 4

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Autocrine Signaling

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49 Terms

1

Autocrine Signaling

Cell secretes ligand

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Juxtacrine Signaling

Signaling via direct cell contact between sender and receiver.

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Paracrine Signaling

Cell secretes ligand affecting nearby cells; local regulators.

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4

Endocrine Signaling

Long-distance ligand travel; hormones like insulin.

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5

Signal Transduction

Process determining cell response to environmental signals.

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6

Ligands

Chemical signals for cell communication; e.g.

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7

Hydrophilic Ligands

Ligands interacting with cell membrane receptors.

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Hydrophobic Ligands

Ligands crossing cell membrane

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9

Reception

Initial step in signal transduction; ligand binding to target cell receptor.

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10

Feedback Mechanisms

Regulate cell signaling processes to maintain homeostasis.

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11

Gene Expression

Process where genes synthesize proteins; regulated by ligands.

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12

Cell Growth and Division

Controlled by signal transduction pathways in response to ligands.

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13

Disruptions in Signal Transduction Pathways

Abnormalities affecting cell response to environmental signals.

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14

Receptor

Protein on cell membrane or in cytosol binding ligands

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15

Conformational Change

Shape change in receptor upon ligand binding

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16

Transduction

Chemical reactions post-ligand binding guiding cell response

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Signaling Cascades

Series of reactions amplifying cell response to a signal

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18

Kinases

Enzymes transferring phosphate groups to activate molecules

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19

Phosphatases

Enzymes removing phosphate groups to inactivate molecules

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20

Enzymes

Proteins producing secondary messengers like cAMP

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21

Response

Final step resulting from ligand interaction

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22

Disruptions in Pathways

Mutations affecting ligand-receptor interactions or signaling

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23

Negative Feedback

System returning to normal state to maintain stability

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24

Insulin

Hormone lowering blood glucose levels by promoting glucose absorption

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25

Glucagon

Hormone raising blood glucose levels by stimulating glycogen breakdown

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Positive Feedback

Process amplifying cell processes

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27

Homeostasis

Internal stability and balance in living organisms

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28

Cell Cycle

Series of stages for cell growth

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29

Interphase

Longest phase preparing cell for division and DNA replication

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Mitosis

Cell division ensuring accurate genome transfer to daughter cells

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Cytokinesis

Division of cytoplasm and cellular contents after mitosis

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G0 Phase

Stage where nondividing cells exit the cell cycle

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Prophase

Mitotic phase with condensed chromosomes and spindle fiber formation

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34

Metaphase

Chromosomes aligning along the cell equator in mitosis

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Anaphase

Chromatids splitting and moving to opposite cell ends in mitosis

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Telophase

Nuclear membranes forming around separated chromosomes in mitosis

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G0 phase

Cell cycle phase where cells may enter at any point

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Cell cycle checkpoints

Regulatory points during the cell cycle ensuring proper progression

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39

Cyclin-dependent kinases

Enzymes adding phosphate groups to molecules

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40

Cyclins

Proteins varying in levels

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41

Mitosis-promoting factor (MPF)

Complex formed by cyclin-dependent kinases bound to cyclins

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42

Somatic cells

Non-reproductive cells in an organism

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43

Density-dependent inhibition

Regulation of cell division based on cell density

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44

Anchorage dependence

Requirement for cells to be attached to a surface to divide

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45

Proto-oncogenes

Genes regulating controlled cell growth

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46

Oncogenes

Mutated proto-oncogenes promoting uncontrolled cell division

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47

Tumor suppressor genes

Genes coding for proteins that prevent abnormal cell division

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48

Apoptosis

Programmed cell death

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49

BRCA gene

Tumor suppressor gene mutation linked to increased cancer risk

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