Autocrine Signaling
Cell secretes ligand
Juxtacrine Signaling
Signaling via direct cell contact between sender and receiver.
Paracrine Signaling
Cell secretes ligand affecting nearby cells; local regulators.
Endocrine Signaling
Long-distance ligand travel; hormones like insulin.
Signal Transduction
Process determining cell response to environmental signals.
Ligands
Chemical signals for cell communication; e.g.
Hydrophilic Ligands
Ligands interacting with cell membrane receptors.
Hydrophobic Ligands
Ligands crossing cell membrane
Reception
Initial step in signal transduction; ligand binding to target cell receptor.
Feedback Mechanisms
Regulate cell signaling processes to maintain homeostasis.
Gene Expression
Process where genes synthesize proteins; regulated by ligands.
Cell Growth and Division
Controlled by signal transduction pathways in response to ligands.
Disruptions in Signal Transduction Pathways
Abnormalities affecting cell response to environmental signals.
Receptor
Protein on cell membrane or in cytosol binding ligands
Conformational Change
Shape change in receptor upon ligand binding
Transduction
Chemical reactions post-ligand binding guiding cell response
Signaling Cascades
Series of reactions amplifying cell response to a signal
Kinases
Enzymes transferring phosphate groups to activate molecules
Phosphatases
Enzymes removing phosphate groups to inactivate molecules
Enzymes
Proteins producing secondary messengers like cAMP
Response
Final step resulting from ligand interaction
Disruptions in Pathways
Mutations affecting ligand-receptor interactions or signaling
Negative Feedback
System returning to normal state to maintain stability
Insulin
Hormone lowering blood glucose levels by promoting glucose absorption
Glucagon
Hormone raising blood glucose levels by stimulating glycogen breakdown
Positive Feedback
Process amplifying cell processes
Homeostasis
Internal stability and balance in living organisms
Cell Cycle
Series of stages for cell growth
Interphase
Longest phase preparing cell for division and DNA replication
Mitosis
Cell division ensuring accurate genome transfer to daughter cells
Cytokinesis
Division of cytoplasm and cellular contents after mitosis
G0 Phase
Stage where nondividing cells exit the cell cycle
Prophase
Mitotic phase with condensed chromosomes and spindle fiber formation
Metaphase
Chromosomes aligning along the cell equator in mitosis
Anaphase
Chromatids splitting and moving to opposite cell ends in mitosis
Telophase
Nuclear membranes forming around separated chromosomes in mitosis
G0 phase
Cell cycle phase where cells may enter at any point
Cell cycle checkpoints
Regulatory points during the cell cycle ensuring proper progression
Cyclin-dependent kinases
Enzymes adding phosphate groups to molecules
Cyclins
Proteins varying in levels
Mitosis-promoting factor (MPF)
Complex formed by cyclin-dependent kinases bound to cyclins
Somatic cells
Non-reproductive cells in an organism
Density-dependent inhibition
Regulation of cell division based on cell density
Anchorage dependence
Requirement for cells to be attached to a surface to divide
Proto-oncogenes
Genes regulating controlled cell growth
Oncogenes
Mutated proto-oncogenes promoting uncontrolled cell division
Tumor suppressor genes
Genes coding for proteins that prevent abnormal cell division
Apoptosis
Programmed cell death
BRCA gene
Tumor suppressor gene mutation linked to increased cancer risk