Chapter 38: Poisoning by Therapeutic Substances 

It acts by inhibiting prostaglandin synthesis.

It can produce severe liver damage due to the accumulation of a highly toxic intermediate metabolite: nacetylepbenzoquinone (NAPQ) in overdosage.

This therapeutic substance is one of the few that has been used repeatedly for homicide and is not infrequently used for suicide, usually amongst nurses and doctors who have access to large doses.

It is a potent hypoglycaemic agent and if the severe lowering of blood sugar persists for many hours, then brain damage and death will occur.Cp

Common symptoms are flushed face, edema of the face, skin rash, tinnitus, deafness, hyperpnoea, nausea, vomiting, haematemesis, melaena, hypoprothrombinaemia, acute renal failure, pulmonary edema, respiratory arrest.

It acts by inhibiting prostaglandin synthesis.

The specific antidote of choice for Paracetamol poisoning.