SBI3U Animal: Structure and Function

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Why we eat

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Biology

11th

111 Terms

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Why we eat

  • Growth

    • Most nutrients break down into smaller molecules that are used to build bone muscles and other types of cells/tissues

    • New cells are produced

  • Maintenance

    • Damaged cells are repaired

    • Dead cells are replaced

  • Energy

    • Fuels biological processes and physical activities

    • Obtain chemical energy carried by plants and animals

    • Stored in cells then released when needed

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Endotherms and Ectotherms

  • Endothermic (warm-blooded)

    • Energy from food is used to maintain constant body temperature

    • More nutrients are needed to support loss of energy

    • Larger endotherms need a consume larger quantities than smaller organisms

  • Ectothermic (cold-blooded)

    • Do not need as much energy to maintain body temperature

    • Energy comes from sources in their environment

    • Energy is not wasted in heating their body

    • Not as adaptable to cold environments

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Metabolism and Related Notes

  • Metabolism

    • The total of all chemical reactions in an organism

    • Anabolism + Catabolism = Metabolism

  • Anabolism

    • Building up complex substances from simpler substances

  • Catabolism

    • Breaking up complex substances into simpler substances

  • Metabolic Rate

    • The rate at which metabolism occurs in an organism

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Metabolic Rate Trends

  • Body Size

    • The larger the body the more energy is required to stay alive

  • Physical Activity

    • Muscles burn more energy than fat

  • Sex

    • Males are typically larger in size and have a greater proportion of muscle mass than females of the same size, age, and fitness level

  • Age

  • Metabolic rate decreases with age

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Food as Fuel

  • Cells need energy to function

  • Nutrients from food are digested and circulated throughout the body

  • A nutrient is any substance that has a useful function in the body

  • Calorie

    • Heat required to raise the temperature of 1 gram of water by 1°C

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Classification of Food

  • Organic and Inorganic

  • Macronutrients and Micronutrients

  • Example: Complex Carbohydrates or minerals (such as calcium)

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Organic vs. Inorganic

  • Organic

    • Produced by living organisms

    • Carbohydrates, fats, proteins, vitamins

  • Inorganic

    • From rocks, soil, and seas

    • Water and minerals

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Macronutrients vs. Micronutrients

  • Macronutrients

    • Needed in large amounts

    • Carbohydrates, Fats, Proteins

  • Micronutrients

    • Needed in small amounts

    • Vitamins and Minerals

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Carbohydrates

  • Composed of carbon, hydrogen, and oxygen

  • Major source of energy

  • Often called “sugars”

    • Ready source of glucose

  • Excess stored as fat or glycogen

  • Cellulose (fibre) is indigestible but important

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Fats (Lipids)

  • Concentrated source of energy

    • Double the energy of carbs

  • Made of C, H, and O but in different ratios

  • Used for insulation, forming cell membranes, protecting vital organs, and increasing nerve transmission

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Types of Fats

  • Unsaturated Fats

    • Liquid at room temperature

    • Easier to digest

    • E.g. olive oil and canola oil

  • Saturated Fats

    • Solid at room temperature

    • Harder to digest

    • E.g. butter and lard

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Proteins

  • Most abundant compound in the body

  • Used throughout the body

    • Structure for skin, bones, and organs

    • Also enzymes and hormones

  • Made of 20 amino acids

    • 8 are essential (get from diet)

  • Meat, eggs, milk, and fish

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Micronutrients

  • Not an energy source

  • Consumed in small amounts

  • Vitamins

    • Muscle and growth function

    • Often act as coenzymes

  • Minerals

    • Iron (blood)

    • Calcium (bones)

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Water

  • Most abundant substance in the body

  • 90% of blood plasma

  • Transports all nutrients

  • Forms extracellular fluid between cells

  • Regulates body temperature

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The Digestive System

  • Digestion is the process of converting food substances to a state in which they can be absorbed by the lining of the digestive tract

  • Long tube open at both ends (Gastrointestinal tract or GI tract)

  • Also has accessory organs

  • Nutrients absorbed, waste eliminated

  • Converts food into usable form

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Stages of Digestion

  • Ingestion

  • Digestion

  • Absorption

  • Egestion/Excretion

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Stage 1: Ingestion

  • Food enters the oral cavity (mouth)

  • In humans, digestion begins in the mouth

    • Salivary Glands (3 Pairs)

    • Secrete Saliva

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Stage 2: Digestion (1)

  • Teeth chew, saliva moistens

  • Enzyme in saliva (amylase) breaks down carbohydrates

  • Muscular tongue pushes food back to pharynx

  • Epiglottis - flap covers trachea so food does not get in

  • Food stretches walls of esophagus and travels downward through waves of contractions called peristalsis

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Food enters the Stomach

  • Food enters the stomach as a bolus (A round ball of food that has been moistened so it can be swallowed)

  • The bolus enters the stomach through the cardiac sphincter

  • Stomach has extensive folds called rugae

  • Layers of smooth muscle help stomach contract and break food down further

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Esophagus to Stomach

  • Peristaltic contractions move the food to the stomach where storage and mixing of food occurs

  • Cardiac sphincter at the top and pyloric sphincter at the bottom to keep food in stomach

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Stage 2: Digestion (2)

  • Food moves in and out of the stomach through sphincters (circular muscles)

  • The stomach contracts and relaxes to churn the food (mechanical digestion)

    • Hydrochloric acid

      • Breaks down food, destroys bacteria in food

    • Pepsin

      • Breaks down proteins into polypeptides

    • Mucus

      • Protects stomach lining from acid and ulcers

  • Some absorption occurs in the stomach

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Mechanical Digestion

  • Physical breakdown of food

    • Mouth (chewing) and stomach (churning)

  • Movement of food

    • Peristalsis

      • Wave-like muscle contractions

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Chemical Digestion

  • In mouth, stomach, and small intestine

  • Chemicals (eg. HCl) and enzymes break down complex molecules in food

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When food is Present…

  • Gastrin

    • Nerves in stomach detect food and release the hormone gastrin into bloodstream

    • Transported to gastric cells where it stimulates gastric juice release

  • Gastric juice (HCl) is very acidic with a pH of 2.0

    • Kills microorganisms, stops amylase, and activates pepsinogen into pepsin (its active form)

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Pepsin

  • The active form of pepsinogen

  • Protein-digesting enzyme produced in the stomach

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Stage 2: Digestion (3)

  • Chyme is released into duodenum through the pyloric sphincter

  • Small Intestine

    • Up to 7 metres in length, 2.5 centimetres in diameter

    • 3 parts

      • Duodenum - enzymes added, digestion

      • Jejunum - digestion, some absorption

      • Ileum - majority of nutrient absorption

    • Secretes the enzyme peptidase which completes the digestion of proteins

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Duodenum

  • First section of the small intestine

  • Basic pH (alkaline)

    • Neutralizes acidic chyme from stomach and inactivates pepsin back to pepsinogen

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Stage 3: Absorption

  • Primary site of nutrient absorption to blood

  • 80% of nutrient absorption occurs here - diffusion

  • Only the small intestine can absorb lipids (fats), carbohydrates, and amino acids (from proteins)

  • Small intestine is lined with villi and microvilli

    • Finger-like projections that increase surface area for absorption

      • Villi

        • Small, finger-like projections

      • Microvilli

        • Microscopic projections of epithelial cells

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Within each villus…

  • Capillary Network

    • All nutrients, except fats, enter bloodstream via capillaries

  • Lacteal

    • Lymphatic vessel through which fats enter the circulatory system

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Large Intestine (1)

  • 1.5 metres in length

  • AKA colon

  • Primary function is to reabsorb fluids and electrolytes

  • Harmless bacteria live here producing Vitamins K and B

  • Any undigested food that remains is called feces

  • Fecal matter is stored here before elimination through the anus

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The Appendix

  • Small organ attached to the caecum

  • It was thought to be vestigial for a long time but now scientists believe that it may harbor small amounts of beneficial bacteria to repopulate intestinal flora after a bad diarrhea incident or antibiotic use

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The Large Intestine (2)

  • The small intestine and the large intestine join at the caecum with the ileocecal valve

  • Large intestine = caecum + colon + rectum

  • 4 parts to the colon:

    • Ascending colon

    • Transverse colon

    • Descending colon

    • Sigmoid colon

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Remember… (The Digestive System)

  • As digested matter passes through the colon, any excess water is absorbed back into the body

  • Vitamins and ions are absorbed with the water

  • Rectum holds solid waste until time for elimination through the anus

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Stage 4: Egestion/Excretion

  • Occurs in the large intestine

  • Main components of feces

    • Cellulose

    • Living and dead bacteria

    • Water

  • Toxic wastes are removed

  • People who eat less cellulose have fewer bowel movements and are at risk of colon cancer

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Accessory Organs of the Digestive System

  • Salivary Glands

    • Parotid Glands

    • Sublingual Glands

    • Submandibular Glands

  • Liver

  • Gallbladder

  • Pancreas

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Salivary Glands

  • Parotid glands secrete watery fluid that contains salivary amylase

  • Other two glands produce slippery mucus to help swallow food bolus

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Liver

  • Second largest organ in the body

  • Produces bile

    • Emulsifies fats

  • Filters the blood

    • Extracts toxins and prepares nutrients for circulation

  • Stores glucose as glycogen

    • Regulates metabolism (blood sugar levels)

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Gallbladder

  • Receives, stores, and concentrates bile from liver

  • When fats enter duodenum, duodenum releases hormone CCK

    • CCK signals the gallbladder to secrete bile to duodenum to emulsify fats

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Pancreas

  • Finger/leaf shaped organ that cradles below and behind the stomach

  • Secretes hormones and enzymes

  • Acidity of chyme entering small intestine from stomach signals duodenum to secrete hormone secretin

    • Secretin stimulates the pancreas to release sodium bicarbonate

  • Other pancreatic digestive enzymes:

    • Lipases (break down fats)

    • Proteases (break down proteins)

    • Carbohydrases (break down carbohydrates)

  • Secretes insulin and glucagon hormones to regulate blood sugar levels

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Homeostasis

  • Maintenance of steady internal state

  • Maintained through negative feedback loops

  • Example: Insulin regulates blood sugar levels

    • Normal levels between 4-6 mmol/L

    • Blood sugar levels increase (e.g. after a meal)

      • Pancreas releases insulin

      • Uptake in glucose from blood to cell

    • Blood sugar levels decrease (e.g. skipped a meal)

      • Pancreas releases glucagon

      • Glucagon causes liver to release glucose into bloodstream

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Enzymes

  • Pepsin

    • Produced by stomach

    • Active in stomach

      • Only when pH is low

    • Acts upon proteins

  • Bile

    • Produced by liver

    • Present in gallbladder and active in small intestine

    • Acts upon carbohydrates

  • Amylase

    • Produced by salivary glands

    • Present/active in mouth/saliva

    • Acts upon starches

  • Hydrochloric acid

    • Produced by stomach

    • Present/active in stomach

    • Provides proper pH for pepsin (to break down proteins)

  • Lipases, Proteases, and Carbohydrases

    • Produced by pancreas

    • Present/active in small intestine

    • Act upon fats, proteins, and carbohydrates

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Chron’s Disease

  • Chronic inflammatory bowel disease

  • Most common in the small/large intestine

  • Causes:

    • Possible hereditary link to autoimmune disease (25%)

    • Possible bacterial or viral infection

  • Symptoms

    • Abdominal pain

    • Intestinal bleeding

    • Diarrhea

    • Nausea and vomiting

    • Loss of appetite

    • Weight loss

    • Fever

  • Diagnosis

    • Barium X-ray

    • Colonoscopy

  • Treatment

    • No cure

    • Medication to control inflammation or associated problems

    • Avoidance of “trigger foods”

    • Removal of blocked segments

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Stomach (Gastric) Cancer

  • Cancer of tissues lining stomach

  • Exact cause unknown

  • Risk factors:

    • H. Pylori Infection

    • Smoking

    • Poor diet

  • Symptoms

    • Nausea and vomiting

    • Heartburn and indigestion

    • Fatigue

    • Stomach pain

    • Feeling full after eating little

  • Diagnosis

    • Barium swallow x-ray

    • Endoscopy or biopsy

    • CT scans

  • Treatment

    • Radiation therapy or chemotherapy

      • To shrink tumour

    • Gastrectomy

      • Partial or total removal

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Cirrhosis

  • Scarring of the liver

  • Leads to loss of liver function

  • Caused by chronic damage to liver (e.g. hepatitis and alcoholism)

  • Symptoms

    • Fatigue

    • Loss of appetite

    • Easy bruising and bleeding

    • Nausea and vomiting

    • Fluid retention in abdominal region

  • Diagnosis

    • Blood tests

    • Ultrasound

    • Liver biopsy

    • CT or MRI scan

  • Treatment

    • Damage cannot be reversed

    • Avoidance of alcohol

    • Liver transplant

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Blood Vessels

  • Arteries

    • Thick-walled vessels that always carry oxygenated blood away from the heart

  • Veins

    • Thin-walled vessels that always carry deoxygenated blood towards the heart

  • Arteries→Arterioles→Capillaries→Venules→Veins

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Arteries

  • Transports blood under pressure

  • Blood moves in a pulse-like wave throughout the circulatory system

  • Arterioles

    • Have smaller diameter than arteries and are less elastic

    • Contraction and relaxation of arteries is the major determinant of the overall blood pressure

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Capillaries

  • Narrowest of all blood vessels

  • RBCs travel in a single file

  • Branching of the capillaries increases surface area for diffusion

  • Connects the arterial and venous systems

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Veins

  • Thinner walls, larger diameter, less muscle than arteries, and they contain valves

  • Contains 70% of total blood volume

  • Most veins must work against gravity

    • Allow one-way flow of blood

    • Contraction of skeletal muscles moves blood toward heart

    • If veins are constantly stretched, they will lose their elasticity and varicose veins will form

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The Heart

  • Size of your fist

  • Hardest-working muscle in the body

  • Contains 4 chambers

    • Left and right atria (receiving chambers)

    • Left and right ventricles (delivery chambers)

  • The left and right sides of the right are separated by a muscular septum

  • The heart is protected by the ribcage, sternum, and spine

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Pathways of Blood

  • Pulmonary Circuit

    • Pumps blood to lungs

    • Right side of the heart

    • Low-pressure system

  • Systemic Circuit

    • Pumps blood to the rest of the body

    • Left side of the heart

    • High-pressure system

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Pulmonary Circuit

Vena Cava (Superior & Inferior)→Right Atrium→Tricuspid Valve/Right AV Valve→Right Ventricle→Pulmonary Semilunar Valve→Pulmonary Trunk→Pulmonary Arteries→Lungs’ Capillaries→Pulmonary Veins→Left Atrium

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Systemic Circuit

Left Atrium→Bicuspid Valve/Left AV Valve/Matrial Valve→Left Ventricle→Aortic Semilunar Valve→Aorta→Smaller Systemic Arteries→Arterioles→Capillaries→Venules→Veins→Vena Cava (Superior & Inferior)→Right Atrium

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Coronary Circulation

  • Delivers oxygenated blood directly to the heart

  • Consists of the left and right coronary arteries

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Cardiac Contractions

  • The heart’s intrinsic contractions are maintained by the sinoatrial (SA) node in the right atrium

  • The nerves can control the strength and rate of the heart’s contractions

  • The SA node passes the signal through the atrioventricular (AV) node

  • There is a 0.1 second delay the AV node before the signal travels to the ventricles

  • The signal travels to the ventricles via the Perkinje fibres and the Bundle of His

  • The signal delay cause the atria to contract simultaneously before the ventricles

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Specialization of Cardiac Muscle

The rhythmic contractions of the heart are due to special characteristics of cardiac muscle cells

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Coronary Artery Disease

  • Plaque buildup in coronary arteries

  • Prevents the heart from oxygen-rich blood

  • Causes/Risk Factors

    • Smoking and Alcoholism

    • High Blood Pressure

    • High Blood Cholesterol

    • Stress

    • Diabetes

    • Obesity

    • Lack of Physical Activity

    • Age, Gender, and Family History

  • Symptoms

    • Shortness of Breath

    • Angina

  • Diagnosis

    • Electrocardiogram

    • Echocardiogram

    • Chest X-ray

    • Blood tests

  • Treatment

    • Angioplasty

    • Coronary Artery Bypass Surgery

    • Medications

      • Decrease blood pressure, blood cholesterol, etc.

    • Lifestyle Changes

      • Increase physical activity and focus on healthy diet

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Leukemia

  • Bone Marrow Cancer: Abnormal WBC overproduction

  • WBCs do not die properly

  • Bone Marrow Overcrowding

  • Reduced RBC, platelet production

  • Causes/Risk Factors

    • Radiation/Chemotherapy

    • Benzene Exposure

    • Smoking

  • Symptoms

    • Swollen, pain-free lymph nodes

    • Bleeding and bruising easily

    • Fevers and night sweats

    • Frequent infections

    • Fatigue

    • Unexplained weight loss

  • Diagnosis

    • Physical Exam

      • Swollen lymph nodes, spleen, liver

    • Blood Test

      • High WBCs and/or Low hemoglobin and platelets

    • Bone Marrow Biopsy

  • Treatment

    • Bone Marrow Transplant

    • Chemotherapy

    • Radiation Therapy

    • Stem Cell Transplant

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Marfan’s Syndrome

  • Heritable disease that affects connective tissue

  • 25% of all cases are a result of a spontaneous mutation

  • Symptoms

    • Tall and Slender

    • Retinal Displacement

    • Aortic Dilation

      • Easily puncturable leading to sudden death

    • Leaky Heart Valves

      • Heart murmour

  • Diagnosis

    • Physical Exam

    • Genetic Analysis

      • Rarely Completed

  • Treatment

    • Skeletal: Orthopedic Braces and Surgery

    • Vision: Surgery and Glasses

    • Heart: Medications, Valve Replacements, Aortic Repair

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The Cardiac Cycle

  • A continuous cycle of contraction and relaxation

  • Systole

    • Heart Contraction

  • Diastole

    • Heart Relaxation

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Systole

  • Atria contract to further fill the ventricles

  • The Tricuspid and Bicuspid valves forced closed due to an increase in ventricular pressure

  • Ventricles contract to force blood from the heart

  • Right Ventricle→(Open Pulmonary Semilunar Valve)→Pulmonary Trunk→Pulmonary Arteries

  • Left Ventricle→(Open Aortic Semilunar Valve)→Aorta

  • Blood pressure is increased (120 mm Hg)

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Diastole

  • Blood enters all four chambers:

    • Pulmonary Veins→Left Atrium

    • Vena Cava (Superior & Inferior)→Right Atrium

  • The Tricuspid and Bicuspid Valves are open, allowing blood to flow into the left and right ventricles

  • The Pulmonary and Aortic Semilunar Valves close due to a decrease in ventricular pressure

  • Blood pressure is reduced (80 mm Hg)

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Lub Dub

  • Heart valves open and close at different times to ensure blood flows in the proper direction

  • Lub:” Tricuspid and Bicuspid valves close (Beginning of systole)

  • Dub:” Pulmonary and Aortic Semilunar valves close (End of Systole)

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Some Common Causes of High Blood Pressure

  • Generally these cause blood vessels to get narrow and/or your heart to beat faster

  • Some examples:

    • Poor diet

    • Kidney and hormone problems, diabetes, and high cholesterol

    • Family history or genetic predisposition

    • Lack of physical activity

    • Older age

    • Being overweight or obese

    • Some medicines

    • Tobacco and/or alcohol use

    • Stress

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Blood Pressure

  • Larger Arteries

    • Blood Pressure: High

    • Velocity: High

    • Total Area: Low

  • Smaller Arteries

    • Blood Pressure: Slightly lower than larger arteries

    • Velocity: Slightly lower than larger arteries

    • Total Area: Slightly higher than larger arteries

  • Arterioles:

    • Blood Pressure: Lower than smaller arteries

    • Velocity: Lower than smaller arteries

    • Total Area: Higher than smaller arteries

  • Capillaries

    • Blood Pressure: Low

    • Velocity: Very low

    • Total Area: Highest

  • Venules

    • Blood Pressure: Low

    • Velocity: Low

    • Total Area: High

  • Veins

    • Blood Pressure: Low

    • Velocity: Moderate

    • Total Area: Low

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Altitude & Oxygen

  • Altitude increases, oxygen concentration decreases

  • Body temporarily increases blood pressure & heart rate

  • Adaptation occurs over a couple of days

  • Body produces hemoglobin and red blood cells

  • Enhanced oxygen-carrying capacity

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Altitude Training

  • Athletes live and train at high altitudes before events

  • Increases red blood cell mass and hemoglobin

  • Enhanced oxygen-carrying capacity in blood

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Cellular Respiration

  • Extra energy boosts aerobic cellular respiration

  • Improves VO2 max

  • Delays lactic acid production, soreness, & fatigue

  • Some athletes attempt blood doping

  • Inject extra red blood cells before events

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Blood Doping

  • Athlete donates a pint or two of their own blood

  • Blood is placed in centrifuge and spins at high speeds

  • Red blood cells (oxygen carriers) forced to bottom

  • Liquid part (plasma) drawn off and re-injected into athlete

  • Red blood cells stored (sometimes frozen)

  • Day before competition, stored red blood cells are re-injected

  • Improves blood’s oxygen-carrying capacity

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Components of Blood

  • Blood Plasma

    • 55% of total blood volume

  • Cellular Components

    • 45% of total blood volume

    • Buffy Coat

      • White Blood Cells

      • Platelets

    • Red Blood Cells

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Blood Plasma

  • Yellowish liquid component of blood

  • Holds blood cells in suspension

  • Carries cells, carbon dioxide, and proteins

  • 55% of total blood volume

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Erythrocytes: Red Blood Cells

  • Produced by bone marrow, stored in spleen

  • Constantly destroyed and replaced

  • Distinct biconcave shape

    • Flattened disc, pinched centre

    • Flexible for travelling through blood vessels

  • No nucleus

  • No mitochondria

  • Contains special hemoglobin molecule

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Hemoglobin

  • Complex protein: 4 protein chains, central iron-containing heme group

  • Iron: Gives red blood cells red colour

  • Iron’s function: Binds with oxygen, oxgenates blood

  • Oxygen’s carrying capacity: 4 oxygen molecules per hemoglobin molecule

  • Iron recycling: Occurs in bone marrow

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Leukocytes: White Blood Cells

  • Produced in bone marrow

  • Larger than red blood cells, fewer in number

  • Amoeboid shape

  • Contain nucleus and lysosomes

  • Part of the body’s immune response system

  • Detect and defend against infection and disease

  • Lysosomes: Digest foreign bacteria

  • Pus formation: At the site of infection

  • Pus Components: Living and dead white blood cells, bacteria

  • Pus as natural “soap”

  • WBC increase: Indication of body fighting infection

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Leukemia

  • Cancer of white blood cells

  • Excess white blood cells in bone marrow

  • Bone marrow unable to make other blood cells

  • Can leave bone marrow, travel into bloodstream, and affect other organs

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Platelets

  • Fragments of special cells from bone marrow

  • Important for circulatory system repair

  • Form blood clots

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Blood Clotting

  • Detects damaged blood vessels, bursts, and releases adhesive chemicals

  • Platelets stick together at the site of damage

  • Chemical reactions create strand-like fibrin molecules, form mesh (blood clot)

  • Prevents blood loss, hold vessel wound together

  • Clot supports wound until new tissue grows

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Hemophilia

Absence of clotting proteins in an individual

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The Respiratory System

  • Respiration

    • The exchange of oxygen and carbon dioxide between an individual and their environment

  • The respiratory system supplies oxygen to body cells and removes carbon dioxide

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Components of Respiration

  1. Ventilation (Breathing)

  2. External Respiration

  3. Internal Respiration

  4. Cellular Respiration

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Ventilation (Breathing)

  1. Inhalation: Oxygen is taken in from the external environment

  2. Exhalation: Carbon dioxide is removed from the internal environment

  • Inhaled

    • 78% Nitrogen

    • 21% Oxygen

    • 0.03% Carbon Dioxide

  • Exhaled

    • 78% Nitrogen

    • 16% Oxygen

    • 5% Carbon Dioxide

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External Respiration

  • Gas exchange between the alveoli and the blood vessels (pulmonary capillaries)

  • Alveoli must be moist to allow for diffusion

  • Oxygen diffuses into capillaries and carbon dioxide diffuses out to alveoli

  • The blood carries the oxygen from the lungs to the body cells

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Internal Respiration

  • Gas exchange between the blood and the body cells

  • Oxygen diffuses out of the blood and carbon dioxide diffuses in

  • Allows for cellular respiration to occur

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Cellular Respiration

  • Occurs in the mitochondria of every cell

  • Cells produce ATP (energy) when glucose breaks down in the presence of oxygen

  • Byproducts include water and carbon dioxide

  • C6H12O6 + O2 → H2O + CO2 + ATP

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Anatomy of the Respiratory System

  • Nose (Nares)

  • Nasal & Oral Cavities

  • Pharynx

  • Larynx

  • Trachea

  • Lungs

    • Bronchi & Bronchioles

    • Alveoli

  • Diaphragm

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Nasal & Oral Cavities

  • Air enters through the nares (nostrils)

    • Warmed (capillaries), Filtered (cilia), and moistened

  • Inhaling through the mouth misses some steps

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Pharynx

  • Common path for air and food (throat)

  • Branches into the esophagus and the trachea

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Larynx

  • Vocal chords for sound production, breathing, and swallowing

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Trachea

  • Connects the pharynx to the lungs

  • Rings of cartilage protect the tube from collapsing

  • Divides into a bronchus on each side

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Lungs

  • Joined to the trachea by two bronchi

  • The bronchi divide into smaller bronchioles

  • Each bronchiole ends in an alveolar sac

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Alveoli

  • Tiny, hollow air sacs

    • One cell thick

  • Surrounded by capillary system

  • Functional unit sof the respiratory system

    • Where gas exchange occurs

  • Increases surface area

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Diaphragm

  • Large, dome-shaped sheet of skeletal muscle (voluntary muscle)

  • Under the ribs, separates the thoracic cavity (heart and lungs) from the abdominal cavity (all other organs)

  • Essential to breathing

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Inhalation

  • Diaphragm and intercostal muscles contract

  • Ribs move up and out, chest cavity enlarges, and pressure decreases

  • Air rushes in from higher pressure environment

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Exhalation

  • Diaphragm and intercostal muscles relax

  • Ribs compress, chest cavity gets smaller, and pressure increases

  • Air escapes to lower pressure environment

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Breathing

  • Involuntary inhalation & exhalation

  • Delivers oxygen to alveoli and removes carbon dioxide

  • Medulla Oblongata

    • Brain region that controls breathing

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Gas Exchange

Occurs between the alveoli and the capillaries due to concentration differences

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Control of Breathing

  • Chemoreceptors detect change in blood pH

    • Blood high in CO2 has lower than normal pH

  • Drop in pH causes Medulla Oblongata to stimulate breathing

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Oxygen Transport

  • Oxygen is carried by hemoglobin in red blood cells

  • Hemoglobin picks up oxygen in high concentration areas

  • Hemoglobin releases oxygen in low concentration areas

  • Oxygen binds with hemoglobin via hydrogen bonds

  • oxygen + hemoglobin → oxyhemoglobin

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Carbon Dioxide Transport

  • Carbon dioxide is carried as bicarbonate ions in blood

  • Red blood cells pick up carbon dioxide in high concentration areas

  • Carbon dioxide converted to bicarbonate in red blood cells

  • Bicarbonate converted back to carbon dioxide in low concentration areas

  • Carbon dioxide released from red blood cells

  • carbon dioxide + water → carbonic acid

  • Some carbon dioxide is carried by hemoglobin as carboxyhemoglobin

  • Some carbon dioxide dissolves in blood plasma

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Human Lung Capacity

  • Influenced by many factors:

    • Age

    • Sex

    • Body Position

    • Strength of diaphragm

    • Strength of chest muscles

  • The average human breathes 12-20 times per minute

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Measurements

  • Tidal Volume: The amount of air inhaled and exhaled in a normal breath

  • Inspiratory Reserve Volume: The amount of air inhaled after a normal inhalation

  • Expiratory Reserve Volume: The amount of air forcefully exhaled after a normal exhalation

  • Vital Capacity: The maximum amount of air that can be exhaled

  • Residual Volume: The amount of air remaining in the lungs after a forceful exhalation

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