Why we eat
Growth
Most nutrients break down into smaller molecules that are used to build bone muscles and other types of cells/tissues
New cells are produced
Maintenance
Damaged cells are repaired
Dead cells are replaced
Energy
Fuels biological processes and physical activities
Obtain chemical energy carried by plants and animals
Stored in cells then released when needed
Endotherms and Ectotherms
Endothermic (warm-blooded)
Energy from food is used to maintain constant body temperature
More nutrients are needed to support loss of energy
Larger endotherms need a consume larger quantities than smaller organisms
Ectothermic (cold-blooded)
Do not need as much energy to maintain body temperature
Energy comes from sources in their environment
Energy is not wasted in heating their body
Not as adaptable to cold environments
Metabolism and Related Notes
Metabolism
The total of all chemical reactions in an organism
Anabolism + Catabolism = Metabolism
Anabolism
Building up complex substances from simpler substances
Catabolism
Breaking up complex substances into simpler substances
Metabolic Rate
The rate at which metabolism occurs in an organism
Metabolic Rate Trends
Body Size
The larger the body the more energy is required to stay alive
Physical Activity
Muscles burn more energy than fat
Sex
Males are typically larger in size and have a greater proportion of muscle mass than females of the same size, age, and fitness level
Age
Metabolic rate decreases with age
Food as Fuel
Cells need energy to function
Nutrients from food are digested and circulated throughout the body
A nutrient is any substance that has a useful function in the body
Calorie
Heat required to raise the temperature of 1 gram of water by 1°C
Classification of Food
Organic and Inorganic
Macronutrients and Micronutrients
Example: Complex Carbohydrates or minerals (such as calcium)
Organic vs. Inorganic
Organic
Produced by living organisms
Carbohydrates, fats, proteins, vitamins
Inorganic
From rocks, soil, and seas
Water and minerals
Macronutrients vs. Micronutrients
Macronutrients
Needed in large amounts
Carbohydrates, Fats, Proteins
Micronutrients
Needed in small amounts
Vitamins and Minerals
Carbohydrates
Composed of carbon, hydrogen, and oxygen
Major source of energy
Often called “sugars”
Ready source of glucose
Excess stored as fat or glycogen
Cellulose (fibre) is indigestible but important
Fats (Lipids)
Concentrated source of energy
Double the energy of carbs
Made of C, H, and O but in different ratios
Used for insulation, forming cell membranes, protecting vital organs, and increasing nerve transmission
Types of Fats
Unsaturated Fats
Liquid at room temperature
Easier to digest
E.g. olive oil and canola oil
Saturated Fats
Solid at room temperature
Harder to digest
E.g. butter and lard
Proteins
Most abundant compound in the body
Used throughout the body
Structure for skin, bones, and organs
Also enzymes and hormones
Made of 20 amino acids
8 are essential (get from diet)
Meat, eggs, milk, and fish
Micronutrients
Not an energy source
Consumed in small amounts
Vitamins
Muscle and growth function
Often act as coenzymes
Minerals
Iron (blood)
Calcium (bones)
Water
Most abundant substance in the body
90% of blood plasma
Transports all nutrients
Forms extracellular fluid between cells
Regulates body temperature
The Digestive System
Digestion is the process of converting food substances to a state in which they can be absorbed by the lining of the digestive tract
Long tube open at both ends (Gastrointestinal tract or GI tract)
Also has accessory organs
Nutrients absorbed, waste eliminated
Converts food into usable form
Stages of Digestion
Ingestion
Digestion
Absorption
Egestion/Excretion
Stage 1: Ingestion
Food enters the oral cavity (mouth)
In humans, digestion begins in the mouth
Salivary Glands (3 Pairs)
Secrete Saliva
Stage 2: Digestion (1)
Teeth chew, saliva moistens
Enzyme in saliva (amylase) breaks down carbohydrates
Muscular tongue pushes food back to pharynx
Epiglottis - flap covers trachea so food does not get in
Food stretches walls of esophagus and travels downward through waves of contractions called peristalsis
Food enters the Stomach
Food enters the stomach as a bolus (A round ball of food that has been moistened so it can be swallowed)
The bolus enters the stomach through the cardiac sphincter
Stomach has extensive folds called rugae
Layers of smooth muscle help stomach contract and break food down further
Esophagus to Stomach
Peristaltic contractions move the food to the stomach where storage and mixing of food occurs
Cardiac sphincter at the top and pyloric sphincter at the bottom to keep food in stomach
Stage 2: Digestion (2)
Food moves in and out of the stomach through sphincters (circular muscles)
The stomach contracts and relaxes to churn the food (mechanical digestion)
Hydrochloric acid
Breaks down food, destroys bacteria in food
Pepsin
Breaks down proteins into polypeptides
Mucus
Protects stomach lining from acid and ulcers
Some absorption occurs in the stomach
Mechanical Digestion
Physical breakdown of food
Mouth (chewing) and stomach (churning)
Movement of food
Peristalsis
Wave-like muscle contractions
Chemical Digestion
In mouth, stomach, and small intestine
Chemicals (eg. HCl) and enzymes break down complex molecules in food
When food is Present…
Gastrin
Nerves in stomach detect food and release the hormone gastrin into bloodstream
Transported to gastric cells where it stimulates gastric juice release
Gastric juice (HCl) is very acidic with a pH of 2.0
Kills microorganisms, stops amylase, and activates pepsinogen into pepsin (its active form)
Pepsin
The active form of pepsinogen
Protein-digesting enzyme produced in the stomach
Stage 2: Digestion (3)
Chyme is released into duodenum through the pyloric sphincter
Small Intestine
Up to 7 metres in length, 2.5 centimetres in diameter
3 parts
Duodenum - enzymes added, digestion
Jejunum - digestion, some absorption
Ileum - majority of nutrient absorption
Secretes the enzyme peptidase which completes the digestion of proteins
Duodenum
First section of the small intestine
Basic pH (alkaline)
Neutralizes acidic chyme from stomach and inactivates pepsin back to pepsinogen
Stage 3: Absorption
Primary site of nutrient absorption to blood
80% of nutrient absorption occurs here - diffusion
Only the small intestine can absorb lipids (fats), carbohydrates, and amino acids (from proteins)
Small intestine is lined with villi and microvilli
Finger-like projections that increase surface area for absorption
Villi
Small, finger-like projections
Microvilli
Microscopic projections of epithelial cells
Within each villus…
Capillary Network
All nutrients, except fats, enter bloodstream via capillaries
Lacteal
Lymphatic vessel through which fats enter the circulatory system
Large Intestine (1)
1.5 metres in length
AKA colon
Primary function is to reabsorb fluids and electrolytes
Harmless bacteria live here producing Vitamins K and B
Any undigested food that remains is called feces
Fecal matter is stored here before elimination through the anus
The Appendix
Small organ attached to the caecum
It was thought to be vestigial for a long time but now scientists believe that it may harbor small amounts of beneficial bacteria to repopulate intestinal flora after a bad diarrhea incident or antibiotic use
The Large Intestine (2)
The small intestine and the large intestine join at the caecum with the ileocecal valve
Large intestine = caecum + colon + rectum
4 parts to the colon:
Ascending colon
Transverse colon
Descending colon
Sigmoid colon
Remember… (The Digestive System)
As digested matter passes through the colon, any excess water is absorbed back into the body
Vitamins and ions are absorbed with the water
Rectum holds solid waste until time for elimination through the anus
Stage 4: Egestion/Excretion
Occurs in the large intestine
Main components of feces
Cellulose
Living and dead bacteria
Water
Toxic wastes are removed
People who eat less cellulose have fewer bowel movements and are at risk of colon cancer
Accessory Organs of the Digestive System
Salivary Glands
Parotid Glands
Sublingual Glands
Submandibular Glands
Liver
Gallbladder
Pancreas
Salivary Glands
Parotid glands secrete watery fluid that contains salivary amylase
Other two glands produce slippery mucus to help swallow food bolus
Liver
Second largest organ in the body
Produces bile
Emulsifies fats
Filters the blood
Extracts toxins and prepares nutrients for circulation
Stores glucose as glycogen
Regulates metabolism (blood sugar levels)
Gallbladder
Receives, stores, and concentrates bile from liver
When fats enter duodenum, duodenum releases hormone CCK
CCK signals the gallbladder to secrete bile to duodenum to emulsify fats
Pancreas
Finger/leaf shaped organ that cradles below and behind the stomach
Secretes hormones and enzymes
Acidity of chyme entering small intestine from stomach signals duodenum to secrete hormone secretin
Secretin stimulates the pancreas to release sodium bicarbonate
Other pancreatic digestive enzymes:
Lipases (break down fats)
Proteases (break down proteins)
Carbohydrases (break down carbohydrates)
Secretes insulin and glucagon hormones to regulate blood sugar levels
Homeostasis
Maintenance of steady internal state
Maintained through negative feedback loops
Example: Insulin regulates blood sugar levels
Normal levels between 4-6 mmol/L
Blood sugar levels increase (e.g. after a meal)
Pancreas releases insulin
Uptake in glucose from blood to cell
Blood sugar levels decrease (e.g. skipped a meal)
Pancreas releases glucagon
Glucagon causes liver to release glucose into bloodstream
Enzymes
Pepsin
Produced by stomach
Active in stomach
Only when pH is low
Acts upon proteins
Bile
Produced by liver
Present in gallbladder and active in small intestine
Acts upon carbohydrates
Amylase
Produced by salivary glands
Present/active in mouth/saliva
Acts upon starches
Hydrochloric acid
Produced by stomach
Present/active in stomach
Provides proper pH for pepsin (to break down proteins)
Lipases, Proteases, and Carbohydrases
Produced by pancreas
Present/active in small intestine
Act upon fats, proteins, and carbohydrates
Chron’s Disease
Chronic inflammatory bowel disease
Most common in the small/large intestine
Causes:
Possible hereditary link to autoimmune disease (25%)
Possible bacterial or viral infection
Symptoms
Abdominal pain
Intestinal bleeding
Diarrhea
Nausea and vomiting
Loss of appetite
Weight loss
Fever
Diagnosis
Barium X-ray
Colonoscopy
Treatment
No cure
Medication to control inflammation or associated problems
Avoidance of “trigger foods”
Removal of blocked segments
Stomach (Gastric) Cancer
Cancer of tissues lining stomach
Exact cause unknown
Risk factors:
H. Pylori Infection
Smoking
Poor diet
Symptoms
Nausea and vomiting
Heartburn and indigestion
Fatigue
Stomach pain
Feeling full after eating little
Diagnosis
Barium swallow x-ray
Endoscopy or biopsy
CT scans
Treatment
Radiation therapy or chemotherapy
To shrink tumour
Gastrectomy
Partial or total removal
Cirrhosis
Scarring of the liver
Leads to loss of liver function
Caused by chronic damage to liver (e.g. hepatitis and alcoholism)
Symptoms
Fatigue
Loss of appetite
Easy bruising and bleeding
Nausea and vomiting
Fluid retention in abdominal region
Diagnosis
Blood tests
Ultrasound
Liver biopsy
CT or MRI scan
Treatment
Damage cannot be reversed
Avoidance of alcohol
Liver transplant
Blood Vessels
Arteries
Thick-walled vessels that always carry oxygenated blood away from the heart
Veins
Thin-walled vessels that always carry deoxygenated blood towards the heart
Arteries→Arterioles→Capillaries→Venules→Veins
Arteries
Transports blood under pressure
Blood moves in a pulse-like wave throughout the circulatory system
Arterioles
Have smaller diameter than arteries and are less elastic
Contraction and relaxation of arteries is the major determinant of the overall blood pressure
Capillaries
Narrowest of all blood vessels
RBCs travel in a single file
Branching of the capillaries increases surface area for diffusion
Connects the arterial and venous systems
Veins
Thinner walls, larger diameter, less muscle than arteries, and they contain valves
Contains 70% of total blood volume
Most veins must work against gravity
Allow one-way flow of blood
Contraction of skeletal muscles moves blood toward heart
If veins are constantly stretched, they will lose their elasticity and varicose veins will form
The Heart
Size of your fist
Hardest-working muscle in the body
Contains 4 chambers
Left and right atria (receiving chambers)
Left and right ventricles (delivery chambers)
The left and right sides of the right are separated by a muscular septum
The heart is protected by the ribcage, sternum, and spine
Pathways of Blood
Pulmonary Circuit
Pumps blood to lungs
Right side of the heart
Low-pressure system
Systemic Circuit
Pumps blood to the rest of the body
Left side of the heart
High-pressure system
Pulmonary Circuit
Vena Cava (Superior & Inferior)→Right Atrium→Tricuspid Valve/Right AV Valve→Right Ventricle→Pulmonary Semilunar Valve→Pulmonary Trunk→Pulmonary Arteries→Lungs’ Capillaries→Pulmonary Veins→Left Atrium
Systemic Circuit
Left Atrium→Bicuspid Valve/Left AV Valve/Matrial Valve→Left Ventricle→Aortic Semilunar Valve→Aorta→Smaller Systemic Arteries→Arterioles→Capillaries→Venules→Veins→Vena Cava (Superior & Inferior)→Right Atrium
Coronary Circulation
Delivers oxygenated blood directly to the heart
Consists of the left and right coronary arteries
Cardiac Contractions
The heart’s intrinsic contractions are maintained by the sinoatrial (SA) node in the right atrium
The nerves can control the strength and rate of the heart’s contractions
The SA node passes the signal through the atrioventricular (AV) node
There is a 0.1 second delay the AV node before the signal travels to the ventricles
The signal travels to the ventricles via the Perkinje fibres and the Bundle of His
The signal delay cause the atria to contract simultaneously before the ventricles
Specialization of Cardiac Muscle
The rhythmic contractions of the heart are due to special characteristics of cardiac muscle cells
Coronary Artery Disease
Plaque buildup in coronary arteries
Prevents the heart from oxygen-rich blood
Causes/Risk Factors
Smoking and Alcoholism
High Blood Pressure
High Blood Cholesterol
Stress
Diabetes
Obesity
Lack of Physical Activity
Age, Gender, and Family History
Symptoms
Shortness of Breath
Angina
Diagnosis
Electrocardiogram
Echocardiogram
Chest X-ray
Blood tests
Treatment
Angioplasty
Coronary Artery Bypass Surgery
Medications
Decrease blood pressure, blood cholesterol, etc.
Lifestyle Changes
Increase physical activity and focus on healthy diet
Leukemia
Bone Marrow Cancer: Abnormal WBC overproduction
WBCs do not die properly
Bone Marrow Overcrowding
Reduced RBC, platelet production
Causes/Risk Factors
Radiation/Chemotherapy
Benzene Exposure
Smoking
Symptoms
Swollen, pain-free lymph nodes
Bleeding and bruising easily
Fevers and night sweats
Frequent infections
Fatigue
Unexplained weight loss
Diagnosis
Physical Exam
Swollen lymph nodes, spleen, liver
Blood Test
High WBCs and/or Low hemoglobin and platelets
Bone Marrow Biopsy
Treatment
Bone Marrow Transplant
Chemotherapy
Radiation Therapy
Stem Cell Transplant
Marfan’s Syndrome
Heritable disease that affects connective tissue
25% of all cases are a result of a spontaneous mutation
Symptoms
Tall and Slender
Retinal Displacement
Aortic Dilation
Easily puncturable leading to sudden death
Leaky Heart Valves
Heart murmour
Diagnosis
Physical Exam
Genetic Analysis
Rarely Completed
Treatment
Skeletal: Orthopedic Braces and Surgery
Vision: Surgery and Glasses
Heart: Medications, Valve Replacements, Aortic Repair
The Cardiac Cycle
A continuous cycle of contraction and relaxation
Systole
Heart Contraction
Diastole
Heart Relaxation
Systole
Atria contract to further fill the ventricles
The Tricuspid and Bicuspid valves forced closed due to an increase in ventricular pressure
Ventricles contract to force blood from the heart
Right Ventricle→(Open Pulmonary Semilunar Valve)→Pulmonary Trunk→Pulmonary Arteries
Left Ventricle→(Open Aortic Semilunar Valve)→Aorta
Blood pressure is increased (120 mm Hg)
Diastole
Blood enters all four chambers:
Pulmonary Veins→Left Atrium
Vena Cava (Superior & Inferior)→Right Atrium
The Tricuspid and Bicuspid Valves are open, allowing blood to flow into the left and right ventricles
The Pulmonary and Aortic Semilunar Valves close due to a decrease in ventricular pressure
Blood pressure is reduced (80 mm Hg)
Lub Dub
Heart valves open and close at different times to ensure blood flows in the proper direction
“Lub:” Tricuspid and Bicuspid valves close (Beginning of systole)
“Dub:” Pulmonary and Aortic Semilunar valves close (End of Systole)
Some Common Causes of High Blood Pressure
Generally these cause blood vessels to get narrow and/or your heart to beat faster
Some examples:
Poor diet
Kidney and hormone problems, diabetes, and high cholesterol
Family history or genetic predisposition
Lack of physical activity
Older age
Being overweight or obese
Some medicines
Tobacco and/or alcohol use
Stress
Blood Pressure
Larger Arteries
Blood Pressure: High
Velocity: High
Total Area: Low
Smaller Arteries
Blood Pressure: Slightly lower than larger arteries
Velocity: Slightly lower than larger arteries
Total Area: Slightly higher than larger arteries
Arterioles:
Blood Pressure: Lower than smaller arteries
Velocity: Lower than smaller arteries
Total Area: Higher than smaller arteries
Capillaries
Blood Pressure: Low
Velocity: Very low
Total Area: Highest
Venules
Blood Pressure: Low
Velocity: Low
Total Area: High
Veins
Blood Pressure: Low
Velocity: Moderate
Total Area: Low
Altitude & Oxygen
Altitude increases, oxygen concentration decreases
Body temporarily increases blood pressure & heart rate
Adaptation occurs over a couple of days
Body produces hemoglobin and red blood cells
Enhanced oxygen-carrying capacity
Altitude Training
Athletes live and train at high altitudes before events
Increases red blood cell mass and hemoglobin
Enhanced oxygen-carrying capacity in blood
Cellular Respiration
Extra energy boosts aerobic cellular respiration
Improves VO2 max
Delays lactic acid production, soreness, & fatigue
Some athletes attempt blood doping
Inject extra red blood cells before events
Blood Doping
Athlete donates a pint or two of their own blood
Blood is placed in centrifuge and spins at high speeds
Red blood cells (oxygen carriers) forced to bottom
Liquid part (plasma) drawn off and re-injected into athlete
Red blood cells stored (sometimes frozen)
Day before competition, stored red blood cells are re-injected
Improves blood’s oxygen-carrying capacity
Components of Blood
Blood Plasma
55% of total blood volume
Cellular Components
45% of total blood volume
Buffy Coat
White Blood Cells
Platelets
Red Blood Cells
Blood Plasma
Yellowish liquid component of blood
Holds blood cells in suspension
Carries cells, carbon dioxide, and proteins
55% of total blood volume
Erythrocytes: Red Blood Cells
Produced by bone marrow, stored in spleen
Constantly destroyed and replaced
Distinct biconcave shape
Flattened disc, pinched centre
Flexible for travelling through blood vessels
No nucleus
No mitochondria
Contains special hemoglobin molecule
Hemoglobin
Complex protein: 4 protein chains, central iron-containing heme group
Iron: Gives red blood cells red colour
Iron’s function: Binds with oxygen, oxgenates blood
Oxygen’s carrying capacity: 4 oxygen molecules per hemoglobin molecule
Iron recycling: Occurs in bone marrow
Leukocytes: White Blood Cells
Produced in bone marrow
Larger than red blood cells, fewer in number
Amoeboid shape
Contain nucleus and lysosomes
Part of the body’s immune response system
Detect and defend against infection and disease
Lysosomes: Digest foreign bacteria
Pus formation: At the site of infection
Pus Components: Living and dead white blood cells, bacteria
Pus as natural “soap”
WBC increase: Indication of body fighting infection
Leukemia
Cancer of white blood cells
Excess white blood cells in bone marrow
Bone marrow unable to make other blood cells
Can leave bone marrow, travel into bloodstream, and affect other organs
Platelets
Fragments of special cells from bone marrow
Important for circulatory system repair
Form blood clots
Blood Clotting
Detects damaged blood vessels, bursts, and releases adhesive chemicals
Platelets stick together at the site of damage
Chemical reactions create strand-like fibrin molecules, form mesh (blood clot)
Prevents blood loss, hold vessel wound together
Clot supports wound until new tissue grows
Hemophilia
Absence of clotting proteins in an individual
The Respiratory System
Respiration
The exchange of oxygen and carbon dioxide between an individual and their environment
The respiratory system supplies oxygen to body cells and removes carbon dioxide
Components of Respiration
Ventilation (Breathing)
External Respiration
Internal Respiration
Cellular Respiration
Ventilation (Breathing)
Inhalation: Oxygen is taken in from the external environment
Exhalation: Carbon dioxide is removed from the internal environment
Inhaled
78% Nitrogen
21% Oxygen
0.03% Carbon Dioxide
Exhaled
78% Nitrogen
16% Oxygen
5% Carbon Dioxide
External Respiration
Gas exchange between the alveoli and the blood vessels (pulmonary capillaries)
Alveoli must be moist to allow for diffusion
Oxygen diffuses into capillaries and carbon dioxide diffuses out to alveoli
The blood carries the oxygen from the lungs to the body cells
Internal Respiration
Gas exchange between the blood and the body cells
Oxygen diffuses out of the blood and carbon dioxide diffuses in
Allows for cellular respiration to occur
Cellular Respiration
Occurs in the mitochondria of every cell
Cells produce ATP (energy) when glucose breaks down in the presence of oxygen
Byproducts include water and carbon dioxide
C6H12O6 + O2 → H2O + CO2 + ATP
Anatomy of the Respiratory System
Nose (Nares)
Nasal & Oral Cavities
Pharynx
Larynx
Trachea
Lungs
Bronchi & Bronchioles
Alveoli
Diaphragm
Nasal & Oral Cavities
Air enters through the nares (nostrils)
Warmed (capillaries), Filtered (cilia), and moistened
Inhaling through the mouth misses some steps
Pharynx
Common path for air and food (throat)
Branches into the esophagus and the trachea
Larynx
Vocal chords for sound production, breathing, and swallowing
Trachea
Connects the pharynx to the lungs
Rings of cartilage protect the tube from collapsing
Divides into a bronchus on each side
Lungs
Joined to the trachea by two bronchi
The bronchi divide into smaller bronchioles
Each bronchiole ends in an alveolar sac
Alveoli
Tiny, hollow air sacs
One cell thick
Surrounded by capillary system
Functional unit sof the respiratory system
Where gas exchange occurs
Increases surface area
Diaphragm
Large, dome-shaped sheet of skeletal muscle (voluntary muscle)
Under the ribs, separates the thoracic cavity (heart and lungs) from the abdominal cavity (all other organs)
Essential to breathing
Inhalation
Diaphragm and intercostal muscles contract
Ribs move up and out, chest cavity enlarges, and pressure decreases
Air rushes in from higher pressure environment
Exhalation
Diaphragm and intercostal muscles relax
Ribs compress, chest cavity gets smaller, and pressure increases
Air escapes to lower pressure environment
Breathing
Involuntary inhalation & exhalation
Delivers oxygen to alveoli and removes carbon dioxide
Medulla Oblongata
Brain region that controls breathing
Gas Exchange
Occurs between the alveoli and the capillaries due to concentration differences
Control of Breathing
Chemoreceptors detect change in blood pH
Blood high in CO2 has lower than normal pH
Drop in pH causes Medulla Oblongata to stimulate breathing
Oxygen Transport
Oxygen is carried by hemoglobin in red blood cells
Hemoglobin picks up oxygen in high concentration areas
Hemoglobin releases oxygen in low concentration areas
Oxygen binds with hemoglobin via hydrogen bonds
oxygen + hemoglobin → oxyhemoglobin
Carbon Dioxide Transport
Carbon dioxide is carried as bicarbonate ions in blood
Red blood cells pick up carbon dioxide in high concentration areas
Carbon dioxide converted to bicarbonate in red blood cells
Bicarbonate converted back to carbon dioxide in low concentration areas
Carbon dioxide released from red blood cells
carbon dioxide + water → carbonic acid
Some carbon dioxide is carried by hemoglobin as carboxyhemoglobin
Some carbon dioxide dissolves in blood plasma
Human Lung Capacity
Influenced by many factors:
Age
Sex
Body Position
Strength of diaphragm
Strength of chest muscles
The average human breathes 12-20 times per minute
Measurements
Tidal Volume: The amount of air inhaled and exhaled in a normal breath
Inspiratory Reserve Volume: The amount of air inhaled after a normal inhalation
Expiratory Reserve Volume: The amount of air forcefully exhaled after a normal exhalation
Vital Capacity: The maximum amount of air that can be exhaled
Residual Volume: The amount of air remaining in the lungs after a forceful exhalation