Chapter 18- Control of Gene Expression in Bacteria 

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21 Terms

1

Jacob

________ and Monod coined the term operon to describe a set of coordinately regulated bacterial genes that are transcribed together into one polycistronic mRNA.

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2

E coli

A protein known as the catabolite activator protein (CAP) has long been viewed as exerting positive control of many operons in ________, including the lαc operon.

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3

lactose metabolism

The group of genes involved in ________ was termed the lαc operon.

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4

allosteric regulation

In ________, a small molecule binds to a protein and causes it to change its shape and activity.

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5

inducer

A(n) ________ is a small molecule that triggers transcription of a specific gene.

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6

Positive control

________ occurs when a regulatory protein called an activator binds to DNA and triggers transcription.

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7

Negative control

________ occurs when a regulatory protein called a repressor binds to DNA and shuts down transcription.

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Transcriptional control

________: The cell could make mRNAs only for proteins it needs.

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Negative feedback control

________ is a form of control in which the final product of a pathway inhibits the production of the product.

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10

lαc operon

The repressor binds to a DNA sequence in the ________ called the operator.

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11

Post translational control

________: After translation, many proteins have to be activated by chemical modification, such as the addition of a phosphate group, in order to function.

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Transcriptional control

The cell could make mRNAs only for proteins it needs

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13

Translational control

The cell could prevent the mRNAs for unneeded proteins from being translated

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Post-translational control

After translation, many proteins have to be activated by chemical modification, such as the addition of a phosphate group, in order to function

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15

Translational control

The cell could prevent the mRNAs for unneeded proteins from being translated.

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16

Constitutive mutants

Cells that are abnormal because they produce a product at all times instead of regulating expression of the product are called

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17

Operator

The repressor binds to a DNA sequence in the lαc operon called the

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18

catabolite activator protein (CAP)

has long been viewed as exerting positive control of many operons in E. coli, including the lαc operon.

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19

Co-repressor

The only difference is that for the trp operon the small molecule regulator is called a

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20

Global gene regulation

is the coordinated regulation of many genes.

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21

Regulon

is a set of separate genes and operons at contain the same regulatory sequences and are controlled by a single type of regulatory protein

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