Chapter 15: Potential Therapies

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Small molecule drug candidates

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15 Terms

1

Small molecule drug candidates

________ can be tested using high- throughput screening.

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2

Viruses

________ may be able to carry therapeutic genes into the brain to correct central nervous system diseases.

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3

NGF

________ (Nerve Growth Factor): a trophic factor that slows the destruction of neurons that use acetylcholine.

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4

Procedures

________ can be developed to modify trophic factor- regulated functions in ways that might be useful in the treatment of neurological disorders.

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5

Antibodies

________ can be engineered to modify the interactions and toxicity of misfolded proteins.

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6

Lasers

________ are used to measure whether proteins are clumped inside cells that have been distributed into containers with small molecules.

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inhibit growth

Neutralizing molecules that stop or ________ can help repair damaged nerve fiber tracts in the spinal cord.

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8

Fruit

________ flies that have been modified to carry a mutant gene for Huntingtons are generally too weak & uncoordinated to break out of their pupal case.

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9

Oligodendrocytes

Glial cells that surround axons and make the myelin sheath.

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10

Nogo

________- A: a protein that inhibits nerve regeneration.

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11

potency of the agent

The ________ can be determined by how well it attaches to the receptor /protein target in a test tube.

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12

RNAi

Interfering RNAs.

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13

NGF (Nerve Growth Factor)

A trophic factor that slows the destruction of neurons that use acetylcholine.

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14

Nogo-A

A protein that inhibits nerve regeneration.

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15

Astrocytes

Glial cells that protect and nourish neurons.

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