RA- Heeter

Rheumatoid Arthritis is…

• chronic or acute

• bilateral or asymmetrical

• local or inflammatory

RA is more common in what gender?

RA is typically caused by

2 risk factors for RA

RA causes chronic inflammation of the synovial tissue lining the joint which leads to

Compared to Osteoarthritis, what is different about the joint stiffness that occurs in Rheumatoid Arthritis?

Signs and Symptoms of RA:

Lab tests done on a patients with RA will show elevated…

What joints are primarily affected by RA? How is this different than OA?

In order to diagnosis RA, what is a mandatory requirement?

Are RA treatments for controlling or curing the disease?

Nonpharm treatments of RA:

For low disease activity, what medication is recommended for initial therapy?

For moderate-high disease activity, what DMARD is recommended for initial therapy?

Guidelines prefer not bridging RA therapy with _____________ if possible.

Bridging therapy may be needed for patients with

What is the only thing that can slow the progression of RA?

DMARDs stand:

For therapy with DMARDs, treatment should begin

How long does it take to see effects of therapy from DMARDs?

How are NSAIDs used in the treatment of RA?

Methotrexate belongs to what class of DMARDs

Guidelines recommend methotrexate should be titrated to >___ mg per week.

ADRs of methotrexate

What supplement should be taken with MTX?

Contraindications of MTX

Hydroxychloroquine main ADRs

Leflunomide ADRs

Sulfasalazine is contraindicated in individuals that have a

list the csDMARDs

Which is preferred over the other, csDMARDs or bDMARDs?

bDMARDs are seperated what 2 classes

Names of the TNFi agents:

Name the route all TNFi agents are administered, with the exception of infliximab.

What is the route of Infliximab?

Name the frequency of administration for each TNFi agent:

• adalimumab

• etanercept

• golimumab

• certolizumab

• infliximab

TNFi agents should not be used in patients with

ALL TNFi agents increase the risk of ___________ and _______________.

This specific TNFi agent has increased risk of infusion related reactions

How do we prevent infusion related reactions?

Name of non-TNFi agents

Name the route and frequency for each non-TNFi agent:

• Abatacept

• Tocilizumab

• Rituximab

• Sarilumab

Abatacept should be used with caution if you have

A non-TNFi is used when

ALL non-TNFi agents increase the risk of

All tsDMARDs are what route?

Names of tsDMARDs:

What JAK Inhibitor/ tsDMARD increases the risk of CV morbidity/mortality?

What 2 bDMARDs have been shown to be safe to use throughout the entire pregnancy?

To help reduce GI side effects of Methotrexate, what supplement should be taken?