Chapter 1: Brain Basics

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Second messengers

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73 Terms

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Second messengers

Substances that convey the message of neurotransmitters from the membrane to the internal cell machinery.

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learning and memory

Norepinephrine might play a role in ___________________.

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myelin sheath

Most axons are covered with a(n) ________ that is made by cells called glia.

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Huntingtons Disease

A fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain.

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Central Nervous System

The midbrain also has clusters of neurons that regulate activity in widespread parts of the ________

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Anticonvulsant

________ means "used to prevent or reduce the severity of epileptic fits or other convulsions".

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Colliculus

A small bump, especially one of two pairs in the roof of the midbrain, involved respectively in vision and hearing.

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Acetylcholinesterase

The enzyme that breaks down ACh once it is not needed anymore.

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Alzheimer's, Parkinson's, Korsakoff Syndrome

Deficiencies in norepinephrine occur in people with ___________, _____________, and ____________ ___________

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Dopamine

________ directs the hypothalamus to make hormones.

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auditory reflexes

The colliculi play a critical role in visual & ________ + in relaying this type of information to the thalamus.

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Amino acids

________ are widely distributed throughout the body and brain.

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cerebral cortex

The ________ and all four lobes are in the forebrain.

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Aspirin

________ reduces fever and pain by inhibiting the cyclooxygenase enzyme.

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neuron

The ________ is the basic working unit of the brain.

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neurotransmitters

Drugs bring about their effects by acting like ________________.

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Trophic Factors

________ may also prove useful for new therapies of developmental and degenerative brain diseases.

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Neurons

________ transmit electrical impulses along axons to send a message.

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Synapses

________ are the contact points where neurons communicate.

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Gaseous neurotransmitters

________ dont act at receptor sites.

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Benzodiazepines

________ are organic chemical substances made of two carbon rings.

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GnRH

Neurons in the hypothalamus produce gonadotropin- releasing hormone (________)

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Direct effects of second messengers

________ on genetic materials may lead to long- term alterations in cellular functioning and changes in behavior.

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thyroid and steroid hormones

Receptors for _______ ___ _______ ________ are found in selected populations of neurons in the brain and relevant organs in the body.

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Cerebellum

The ________ has two hemispheres that control the precise timing of movement and cognitive processes.

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Nitric oxide

________ may also be attributed to excess glutamate release that causes stroke and neuronal damage.

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Glycine

________ and gamma- aminobutyric acid (GABA) inhibit the firing of neurons.

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Acute stress

________ increases the release of norepinephrine from sympathetic nerves and the adrenal medulla.

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development of drugs

The ________ that block or stimulate NMDA receptors hold promise for improving brain function and treating neurological and psychological disorders.

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smaller branches

The axon gives rise to ________ & ends at nerve terminals.

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spinal cord

The ________ is the extension of the brain through the vertebral column.

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Prostaglandins

A class of compounds made from lipids made by an enzyme called cyclooxygenase.

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Hormones

________ are taken up from blood and act to affect neuronal activity and aspects of neuronal structure.

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Reproduction

________ in females is a good example of regular cyclic process driven by circulating hormones and involving a feedback loop.

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Myasthenia Gravis

An autoimmune disease characterized by fatigue and muscle weakness caused by the formation of antibodies that attack ACh receptors on skeletal muscle.

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Peptides

Short chains of amino acids synthesized in the cell body.

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Nerve impulses

Nerve impulses involve the opening & closing of ___ ________.

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genes

Thyroid and steroid hormones bind to receptor proteins that in turn bind to DNA and regulate the action of ______.

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PNS

The ________ contains nerves and small concentrations of gray matter called ganglia.

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midbrain

The ________ consists of two pairs of small hills called Colliculi.

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control of behavior

The brain adjusts its performance and ________ in response to changing environment.

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ACh

________ is then released into the synapse where it attaches to ________ receptors on target cells.

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Cerebral cortex/gray matter

A sheet of tissue covering the outermost layer of the cerebrum

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Thalamus

It passes most sensory information onto the cerebral cortex after helping to prioritize that information

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Hypothalamus

The control center for appetite, defensive & reproductive behaviors, and the circadian rhythm

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Cerebral nucleus

A cluster of neurons in the CNS (central nervous system)

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Pavlovian Learning

A learning procedure in which a biologically potent stimulus (e.g. food) is paired with a previously neutral stimulus (e.g. a bell)

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Central Nervous System (CNS)

Formed by the brain and spinal cord

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Peripheral Nervous System (PNS)

Formed by all the other nerves branching off the brain and spinal cord into the body

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Somatic Nervous System

Made up of neurons connecting CNS to the parts of the body that interact with the outside world

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Autonomic Nervous System

Made of neurons connecting the CNS with the internal organs, smooth muscle, and cardiac muscle

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Sympathetic Nervous System

Moves around energy and resources in times of stress

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Parasympathetic Nervous System

Conserves energy during relaxed states and sleep

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Cell body/Soma

The part of the neuron that contains all the cellular machinery it needs to survive (nucleus, mitochondria, etc.)

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Dendrites

Branched extensions of the neuron's cytoplasm that receive messages from other neurons

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Axon

A mostly linear extension of the neurons' cytoplasm that sends messages to other neurons

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Ion channels

Selectively permeable, water-filled molecular tunnels that pass through cell membrane and allow ionsĀ or small molecules to enter/leave the cell

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Membrane potential

The voltage of the cells membrane

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Neurotransmitters

The brain's chemical messengers

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Acetylcholinesterase

The enzyme that breaks down ACh once it is not needed anymore

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Myasthenia Gravis

An autoimmune disease characterized by fatigue and muscle weakness caused by the formation of antibodies that attack ACh receptors on skeletal muscle

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62

Huntingtons Disease

A fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain

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Peptides

Short chains of amino acids synthesized in themcell body

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Endorphins

A class of opiate-like peptides that were named based on the term "endogenous morphine"

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Substance P

A peptide neurotransmitter causing the sensation of burning pain

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Capsaicin

A compound that causes the release of Substance P

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Trophic Factors

Substances needed for development, function, and survival of groups of neurons

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68

In all people this causes the release of two hormones

Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH)

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69

Females

causes ovulation and starts releasing Estrogen and Progesterone

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70

Prostaglandins

A class of compounds made from lipids made by an enzyme called cyclooxygenase

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Second messengers

Substances that convey the message of neurotransmitters from the membrane to the internal cell machinery

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ATP

The source of energy in all cells

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cAMP

Changes the function of ion channels in the membrane and the expression of genes in the nucleus

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