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What are charge carriers?
mostly electrolytes
K+ leaving the cell
hyperpolarization
Na+ entering the cell
depolarization
Resting membrane potential
-70mV
What ion is most permeable in resting cells?
K+
How is resting membrane potential established?
Na+/K+ pump
Is the nervous system involuntary or voluntary?
both
Is the endocrine system involuntary or voluntary?
involuntary
Where are neurotransmitter receptors?
extracellular
What neurotransmitters cause depolarization?
excitatory
What neurotransmitters cause hyperpolarization?
inhibitory
Where are hormones transported?
blood vessels and lymph vessels
Chemicals that exert effects on the same cells that secret them
autocrine
Chemicals released by cells that effect other nearby cells
paracrine
Secretion into the blood for signaling with cells far away
endocrine
Secretion into the ext. environment through a duct, usually epithelium
exocrine
Integration and command center, brain and spinal cord
CNS
Sensory input and motor output, links all body to CNS
PNS
What neurotransmitter is related to the parasympathetic nervous system?
acetylcholine
What neurotransmitter is related to the sympathetic nervous system?
norepinephrine
Supporting cells of the nervous system
glia
glia:neuron ratio
1-5:1
Cells that transmit signals in the nervous system
neurons
Brain is _% of body weight, but uses __% of O2
2, 20
Most abundant, helps regulate composition of extracellular fluid (remove K+ and NT), provides nutrients, CNS
astrocytes
Scavengers that phagocytize debris and remodel synapses, CNS
microglia
Electrical insulation, have processes that wrap axons in myelin sheaths, CNS
oligodendrocytes
Lines cavities where cilia circulate CSF to cushion and nourish CNS
ependymal cells
Surround and form myelin sheaths around axons, PNS
schwann cells
Surround neuron cell body, regulates external chemical environment, PNS
satellite cells
Gaps on axon between myelin sheaths
nodes of ranvier
Part of the cell body that receives input
dendrites
Where does graded potential occur?
dendrites and cell body
Axon size
very short - 1 meter
What special sense cells regenerate?
taste and smell
Normal hearing range of frequencies
20-20,000 Hz
In what part of the ear does sound transmission happen?
middle ear
How much K+ is in the endolymph in the cochlear duct?
about 160mM
Opens mechanically gated ion channels, activates K+ Ca2+ current leading to depolarization and release of glutamate
bending towards tallest stereocilia
Closes mechanically gated ion channels, hyperpolarization, glutamate release inhibited
bending towards shortest sterocilia
Where are the short and stiff fibers in the cochlea?
near oval window
Damage to neural structures at any point from cochlear hair to auditory cortex
sensorineural deafness
Ringing in the ear, some cases damaged hairs keep sending signals to the brain
tinnitus
Blocked sound conduction to fluids of inner ear
conduction deafness
Middle ear infection a.k.a…
otitis media
Membranous sac continuous with cochlear duct
saccule
Membranous sac continuous with semicircular canals
utricle
The saccule and utricle house linear equilibrium receptors called
macula
Ampulla of each canal house rotational equilibrium receptors called
crista ampullaris
When do macula hair cells release neurotransmitters?
continuously
Does the saccule or utricle detect horizontal movements?
utricle
Does the saccule or utricle detect vertical movements?
saccule
What does the receptor activate in the special sense smell?
G protein Golf
What opens the channels to allow for Na and Ca influx in the special sense smell?
cAMP
What is exocytosed in the special sense smell?
Glutamate
What 2 factors can enhance or detract from taste?
temp and texture
What special senses use G-coupled proteins?
vision, smell, taste (sweet, bitter, umami)
What G protein do sweet, bitter, and umami use?
Gustucin
What is the visible wavelength range?
400-700 nm
The cornea and sclera make up what layer of the eye?
fibrous layer
The choroid, ciliary body, and iris make up what layer of the eye?
vascular layer
The retina makes up what layer of the eye?
inner layer
absorbs light, prevents scattering, phagocytized photoreceptor cell fragments, and recycles vit. A for all photoreceptors
outer pigmented layer of the retina
transparent, no BVs, composed of the 3 types of neurons
inner neural layer of the retina
What are the 3 types of neurons in the inner layer of the retina?
photoreceptors, bipolar, and ganglion cells
What is the direction of the signlas through the eye neurons?
photoreceptors to bipolar to ganglion cells
What portion of the photoreceptors contains rods and cones?
outer segment
What G protein does the special sense eye use?
Transducin
cGMP breaks down, channels close, photoreceptors hyperpolarize, = no release of neurotransmitter, bipolar cells depolarize
light on pathway
cGMP increases, channels open, photoreceptors depolarize, = release of neurotransmitter, bipolar cells hyperpolarize
light off pathway
Where is light refracted?
cornea, entering lens, leaving lens
lens flattens, ciliary muscles relax, and suspensory ligaments tense
distant vision
lens bulges, ciliary muscles contract, and suspensory ligaments relax
close vision
nearsighted, eyes too long, focal point in front of retina, needs concave lens
myopia
farsighted, eyes too short, focal point behind retina, needs convex lens
hyperopia
What brings the membrane potential back to negative? (repolarizing)
opening K+ channels
What is the membrane potential threshold for neuron cells?
-55mV
What is the resting membrane potential for neuron cells?
-70mV
What is the maximum amplitude for neuron cells?
30mV
neurons cant respond to another stimulus when Na+ channels are either open or inactivated
absolute refractory period
immediately after the absolute refractory period when Na+ channels reactivate, but needs a stronger stimulus
relative refractory period
What ion assists in the exocytosis of a neurotransmitter onto the post-synaptic membrane?
Ca2+
What are the 2 ways that the resting action potential gets back to normal?
K+ leak channels and Na/K pumps
EPSP
excitatory post-synaptic potential
IPSP
inhibitory post-synaptic potential
1 excitatory signal must yell multiple times louder and louder
temporal summation
multiple excitatory signals yell
spatial summation
What is the hypothalamus hormone’s target?
anterior pituitary gland
Stimulates growth hormone
growth hormone releasing hormone
Inhibits growth hormone
growth hormone inhibiting hormone (somatostatin)
Stimulates thryoid stimulating hormone
thyrotropin releasing hormone
Stimulates follicle stimulated hormone and luteinizing hormone
gonadotropin releasing hormone
Stimulates adrenocorticotropic hormone
corticotropin releasing hormone
Inhibits prolactin
prolactin inhibiting hormone (dopamine)
What 2 hormones arent tropic in the anterior pituitary gland?
prolactin and growth hormone
What are the male and female FSH cells?
sertoli and granulosa
What are the male and female LH cells?
leydig and theca
What cells make androgens in females?
theca cells
What cells convert androgen to estrogen in females?
granulosa cells
What cells make testosterone in males?
leydig cells