HUBS Lecture #21 (Meninges, Ventricular System, and CSF Flow)
Meninges
→ Protective covering of brain
→ Made up of three layers: Dura mater, Arachnoid, Pia mater
Dura Mater
Outermost layer
Tough, dense, fibrous
Two layers: outer, inner
Usually tightly connected
Separation of these layers creates venous sinuses
Inner layer forms dural folds
Venous sinus (Dural sinus)
Separation of inner and outer layers, creating a space
Space collects:
Venous (deoxygenated) blood from brain
“Old” (depleted) cerebrospinal fluid from ventricular system
Dural folds
Formed by inner layer of Dura mater
Separates major brain divisions
Stabilises brain within cranium
THREE TYPES: Falx= sickle shaped
Falx cerebri
Separates cerebral hemispheres
Median plane
Falx cerebelli
Separates cerebellar hemispheres
Median plane
Tentorium (‘tent’) cerebelli
Separates cerebrum and cerebellum
Horizontal plane
Arachnoid
→ “spider-like”
Middle layer (beneath dura mater, above pia mater)
Special features: Subarachnoid space and Arachnoid granulations
Blood vessels sit within the subarachnoid space
Does NOT extend into sulci
Subarachnoid Space
Arachnoid layer suspended above pia mater on “legs”
Filled with cerebrospinal fluid
Liquid layer for cushioning
Blood vessels inside
Arachnoid Granulations
Perforate dura mater
Into venous sinus
Pumps CSF depleted of nutrients into venous sinus
Pia Mater
Innermost layer, closest to the brain
Thin, delicate, transparent
Blood vessels sit on pia mater in arachnoid space
provides some cushioning
Adheres closely to brain therefore providing some stability
follows gyri, extends into sulci
Ventricular System
Network of interconnected ventricles (spaces) within brain
Ventricles filled with CSF
nourishes and protects the brain
Ventricles lined with ependymal cells (glia)
circulate CSF with cilia
Choroid Plexus produces CSF
STRUCTURE, Superior to Interior
Lateral ventricles (2)
One in each cerebral hemisphere
Third ventricle
In diecephalon
Cerebral aqueduct
Midbrain
Connects 3rd and 4th ventricles
Fourth ventricle
at cerebellum level
Central canal of spinal cord
Cerebrospinal Fluid (CSF)
Produced by choroid plexus in ventricles
Surrounds CNS
within arachnoid space
Supports, cushions
Transports nutrients and waste
Circulation
START: Lateral ventricles → Third ventricle → Cerebral aqueduct → Fourth ventricle (SOME: spinal canal) → Subarachnoid space → Arachnoid granulations → Venous sinus: EXIT
HUBS Lecture #21 (Meninges, Ventricular System, and CSF Flow)
Meninges
→ Protective covering of brain
→ Made up of three layers: Dura mater, Arachnoid, Pia mater
Dura Mater
Outermost layer
Tough, dense, fibrous
Two layers: outer, inner
Usually tightly connected
Separation of these layers creates venous sinuses
Inner layer forms dural folds
Venous sinus (Dural sinus)
Separation of inner and outer layers, creating a space
Space collects:
Venous (deoxygenated) blood from brain
“Old” (depleted) cerebrospinal fluid from ventricular system
Dural folds
Formed by inner layer of Dura mater
Separates major brain divisions
Stabilises brain within cranium
THREE TYPES: Falx= sickle shaped
Falx cerebri
Separates cerebral hemispheres
Median plane
Falx cerebelli
Separates cerebellar hemispheres
Median plane
Tentorium (‘tent’) cerebelli
Separates cerebrum and cerebellum
Horizontal plane
Arachnoid
→ “spider-like”
Middle layer (beneath dura mater, above pia mater)
Special features: Subarachnoid space and Arachnoid granulations
Blood vessels sit within the subarachnoid space
Does NOT extend into sulci
Subarachnoid Space
Arachnoid layer suspended above pia mater on “legs”
Filled with cerebrospinal fluid
Liquid layer for cushioning
Blood vessels inside
Arachnoid Granulations
Perforate dura mater
Into venous sinus
Pumps CSF depleted of nutrients into venous sinus
Pia Mater
Innermost layer, closest to the brain
Thin, delicate, transparent
Blood vessels sit on pia mater in arachnoid space
provides some cushioning
Adheres closely to brain therefore providing some stability
follows gyri, extends into sulci
Ventricular System
Network of interconnected ventricles (spaces) within brain
Ventricles filled with CSF
nourishes and protects the brain
Ventricles lined with ependymal cells (glia)
circulate CSF with cilia
Choroid Plexus produces CSF
STRUCTURE, Superior to Interior
Lateral ventricles (2)
One in each cerebral hemisphere
Third ventricle
In diecephalon
Cerebral aqueduct
Midbrain
Connects 3rd and 4th ventricles
Fourth ventricle
at cerebellum level
Central canal of spinal cord
Cerebrospinal Fluid (CSF)
Produced by choroid plexus in ventricles
Surrounds CNS
within arachnoid space
Supports, cushions
Transports nutrients and waste
Circulation
START: Lateral ventricles → Third ventricle → Cerebral aqueduct → Fourth ventricle (SOME: spinal canal) → Subarachnoid space → Arachnoid granulations → Venous sinus: EXIT