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HUBS Lecture #21 (Meninges, Ventricular System, and CSF Flow)

Meninges

→ Protective covering of brain

→ Made up of three layers: Dura mater, Arachnoid, Pia mater

Dura Mater

  • Outermost layer

  • Tough, dense, fibrous

  • Two layers: outer, inner

    • Usually tightly connected

    • Separation of these layers creates venous sinuses

  • Inner layer forms dural folds

Venous sinus (Dural sinus)

  • Separation of inner and outer layers, creating a space

  • Space collects:

    • Venous (deoxygenated) blood from brain

    • “Old” (depleted) cerebrospinal fluid from ventricular system

Dural folds

  • Formed by inner layer of Dura mater

  • Separates major brain divisions

  • Stabilises brain within cranium

THREE TYPES: Falx= sickle shaped

  1. Falx cerebri

    • Separates cerebral hemispheres

    • Median plane

  2. Falx cerebelli

    • Separates cerebellar hemispheres

    • Median plane

  3. Tentorium (‘tent’) cerebelli

    • Separates cerebrum and cerebellum

    • Horizontal plane

Arachnoid

→ “spider-like”

  • Middle layer (beneath dura mater, above pia mater)

  • Special features: Subarachnoid space and Arachnoid granulations

  • Blood vessels sit within the subarachnoid space

  • Does NOT extend into sulci

Subarachnoid Space

  • Arachnoid layer suspended above pia mater on “legs”

  • Filled with cerebrospinal fluid

    • Liquid layer for cushioning

  • Blood vessels inside

Arachnoid Granulations

  • Perforate dura mater

    • Into venous sinus

  • Pumps CSF depleted of nutrients into venous sinus

Pia Mater

  • Innermost layer, closest to the brain

  • Thin, delicate, transparent

  • Blood vessels sit on pia mater in arachnoid space

    • provides some cushioning

  • Adheres closely to brain therefore providing some stability

    • follows gyri, extends into sulci

Ventricular System

  • Network of interconnected ventricles (spaces) within brain

  • Ventricles filled with CSF

    • nourishes and protects the brain

  • Ventricles lined with ependymal cells (glia)

    • circulate CSF with cilia

  • Choroid Plexus produces CSF

STRUCTURE, Superior to Interior

  • Lateral ventricles (2)

    • One in each cerebral hemisphere

  • Third ventricle

    • In diecephalon

  • Cerebral aqueduct

    • Midbrain

    • Connects 3rd and 4th ventricles

  • Fourth ventricle

    • at cerebellum level

  • Central canal of spinal cord

Cerebrospinal Fluid (CSF)

  • Produced by choroid plexus in ventricles

  • Surrounds CNS

    • within arachnoid space

  • Supports, cushions

  • Transports nutrients and waste

Circulation

START: Lateral ventricles → Third ventricle → Cerebral aqueduct → Fourth ventricle (SOME: spinal canal) → Subarachnoid space → Arachnoid granulations → Venous sinus: EXIT

JI

HUBS Lecture #21 (Meninges, Ventricular System, and CSF Flow)

Meninges

→ Protective covering of brain

→ Made up of three layers: Dura mater, Arachnoid, Pia mater

Dura Mater

  • Outermost layer

  • Tough, dense, fibrous

  • Two layers: outer, inner

    • Usually tightly connected

    • Separation of these layers creates venous sinuses

  • Inner layer forms dural folds

Venous sinus (Dural sinus)

  • Separation of inner and outer layers, creating a space

  • Space collects:

    • Venous (deoxygenated) blood from brain

    • “Old” (depleted) cerebrospinal fluid from ventricular system

Dural folds

  • Formed by inner layer of Dura mater

  • Separates major brain divisions

  • Stabilises brain within cranium

THREE TYPES: Falx= sickle shaped

  1. Falx cerebri

    • Separates cerebral hemispheres

    • Median plane

  2. Falx cerebelli

    • Separates cerebellar hemispheres

    • Median plane

  3. Tentorium (‘tent’) cerebelli

    • Separates cerebrum and cerebellum

    • Horizontal plane

Arachnoid

→ “spider-like”

  • Middle layer (beneath dura mater, above pia mater)

  • Special features: Subarachnoid space and Arachnoid granulations

  • Blood vessels sit within the subarachnoid space

  • Does NOT extend into sulci

Subarachnoid Space

  • Arachnoid layer suspended above pia mater on “legs”

  • Filled with cerebrospinal fluid

    • Liquid layer for cushioning

  • Blood vessels inside

Arachnoid Granulations

  • Perforate dura mater

    • Into venous sinus

  • Pumps CSF depleted of nutrients into venous sinus

Pia Mater

  • Innermost layer, closest to the brain

  • Thin, delicate, transparent

  • Blood vessels sit on pia mater in arachnoid space

    • provides some cushioning

  • Adheres closely to brain therefore providing some stability

    • follows gyri, extends into sulci

Ventricular System

  • Network of interconnected ventricles (spaces) within brain

  • Ventricles filled with CSF

    • nourishes and protects the brain

  • Ventricles lined with ependymal cells (glia)

    • circulate CSF with cilia

  • Choroid Plexus produces CSF

STRUCTURE, Superior to Interior

  • Lateral ventricles (2)

    • One in each cerebral hemisphere

  • Third ventricle

    • In diecephalon

  • Cerebral aqueduct

    • Midbrain

    • Connects 3rd and 4th ventricles

  • Fourth ventricle

    • at cerebellum level

  • Central canal of spinal cord

Cerebrospinal Fluid (CSF)

  • Produced by choroid plexus in ventricles

  • Surrounds CNS

    • within arachnoid space

  • Supports, cushions

  • Transports nutrients and waste

Circulation

START: Lateral ventricles → Third ventricle → Cerebral aqueduct → Fourth ventricle (SOME: spinal canal) → Subarachnoid space → Arachnoid granulations → Venous sinus: EXIT