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Chapter 12 - The Cell Cycle

  • The ability of organisms to reproduce more of their own kind is the defining feature that differentiates living things from nonliving materials. This one-of-a-kind ability to reproduce, like other biological processes, has a cellular base.

  • A German physician, Rudolf Virchow, stated in 1855, "Where a cell exists, there must have been a preceding cell, just as the animal develops only from an animal and the plant only from a plant." He summed up this notion with the Latin phrase "Omnis cellula e cellula," which means "Every cell from a cell." The continuation of life is reliant on cell reproduction, or cell division.

  • Cell division serves numerous vital functions throughout life. When a prokaryotic cell divides, it is truly reproducing since the process results in the formation of a new creature (another cell).

  • The same may be said for any unicellular eukaryote, such as the amoeba. In the case of multicellular eukaryotes, cell division allows each of these creatures to grow from a single cell—the fertilized egg.

  • A two-celled embryo has the initial stage in this process. In fully mature multicellular eukaryotes, cell division continues to function in renewal and repair, replacing cells that die from accidents or regular wear and strain. For instance, dividing cells in your bone marrow constantly produce new blood cells.

  • The genome refers to a cell's DNA or genetic information. Although a prokaryotic genome is frequently a single DNA molecule, eukaryotic genomes are typically made up of several DNA molecules.

  • In a eukaryotic cell, the total length of DNA is vast. A normal human cell, for example, has around 2 m of DNA—a length approximately 250,000 times larger than the cell's width.

  • Before the cell can divide to produce genetically identical daughter cells, all of its DNA must be duplicated or replicated, and then the two copies must be separated so that each daughter cell has a full genome.

  • The cell division process is an essential element of the cell cycle, which is a cell's existence from the moment it is produced via the division of a parent cell until it divides into two daughter cells. (Biologists refer to cells as "daughter" or "sister," but this is not intended to suggest gender.)

  • Cell division is essential for the transmission of identical genetic material to cellular progeny. Because a breakdown in cell cycle regulation plays a significant role in the development of cancer, this element of cell biology is a hotly debated topic.

    • The term chromosomes refer to the replication and distribution of so much DNA are manageable because the DNA molecules are packaged into structures, (from the Greek chroma, color, and soma, body), so named because they take up certain dyes used in microscopy.

  • The consequences of abnormal cell activity in the body can be disastrous. The issue starts when a single cell in a tissue experiences the first of several stages that transforms a normal cell into a cancer cell.

  • This type of cell frequently has changed proteins on its surface, and the body's immune system typically detects it as a "nonself"—an insurgent—and eliminates it.

    Breast Cancer Cell

  • If the cell is not destroyed, it may grow and become a tumor, which is a mass of aberrant cells within otherwise normal tissue.

  • If the aberrant cells have too few genetic and cellular alterations to thrive at another location, they may stay in the original site. In that situation, the growth is referred to as a benign tumor.

  • Most benign tumors are not dangerous (depending on their location) and can be removed surgically. A malignant tumor, on the other hand, consists of cells that have undergone genetic and cellular changes that allow them to spread to new tissues and impair the functions of one or more organs; these cells are also sometimes referred to as transformed cells (though usage of this term is generally restricted to cells in culture), as shown in the image attached.

    • The term Cancer refers to being defined as an individual who has a malignant tumor.

  • Aside from excessive proliferation, the alterations that have happened in malignant tumor cells can be seen in a variety of ways.

  • These cells may contain an unusual number of chromosomes, however, whether this is a result of tumor-related alterations is debatable.

  • Their metabolism may be changed, and they may cease to operate in any useful manner. Cancer cells lose their attachments to surrounding cells and the extracellular matrix as a result of abnormal alterations on the cell surface, allowing them to move into neighboring tissues.

  • Cancer cells may also release signaling chemicals that stimulate the growth of blood arteries toward the tumor.

  • A few tumor cells may break out from the primary tumor, penetrate blood arteries and lymph vessels, and spread to distant regions of the body. They may multiply and create a new tumor there, as shown in the image attached above.

  • Metastasis refers to the spread of cancer cells to places other than their initial site. A confined tumor may be treated using high-energy radiation, which destroys DNA in cancer cells far more than DNA in normal cells, perhaps because the majority of cancer cells have lost the ability to repair such damage.

  • Chemotherapy is used to treat known or suspected metastatic cancers, in which medicines that are harmful to actively proliferating cells are given through the circulatory system.

  • Taxol, for example, blocks the mitotic spindle by inhibiting microtubule depolymerization, stopping actively dividing cells from progressing through metaphase and ultimately leading to their death.

  • Chemotherapy side effects are caused by the medicines' impact on normal cells, which divide regularly owing to the role of that cell type in the organism.

T

Chapter 12 - The Cell Cycle

  • The ability of organisms to reproduce more of their own kind is the defining feature that differentiates living things from nonliving materials. This one-of-a-kind ability to reproduce, like other biological processes, has a cellular base.

  • A German physician, Rudolf Virchow, stated in 1855, "Where a cell exists, there must have been a preceding cell, just as the animal develops only from an animal and the plant only from a plant." He summed up this notion with the Latin phrase "Omnis cellula e cellula," which means "Every cell from a cell." The continuation of life is reliant on cell reproduction, or cell division.

  • Cell division serves numerous vital functions throughout life. When a prokaryotic cell divides, it is truly reproducing since the process results in the formation of a new creature (another cell).

  • The same may be said for any unicellular eukaryote, such as the amoeba. In the case of multicellular eukaryotes, cell division allows each of these creatures to grow from a single cell—the fertilized egg.

  • A two-celled embryo has the initial stage in this process. In fully mature multicellular eukaryotes, cell division continues to function in renewal and repair, replacing cells that die from accidents or regular wear and strain. For instance, dividing cells in your bone marrow constantly produce new blood cells.

  • The genome refers to a cell's DNA or genetic information. Although a prokaryotic genome is frequently a single DNA molecule, eukaryotic genomes are typically made up of several DNA molecules.

  • In a eukaryotic cell, the total length of DNA is vast. A normal human cell, for example, has around 2 m of DNA—a length approximately 250,000 times larger than the cell's width.

  • Before the cell can divide to produce genetically identical daughter cells, all of its DNA must be duplicated or replicated, and then the two copies must be separated so that each daughter cell has a full genome.

  • The cell division process is an essential element of the cell cycle, which is a cell's existence from the moment it is produced via the division of a parent cell until it divides into two daughter cells. (Biologists refer to cells as "daughter" or "sister," but this is not intended to suggest gender.)

  • Cell division is essential for the transmission of identical genetic material to cellular progeny. Because a breakdown in cell cycle regulation plays a significant role in the development of cancer, this element of cell biology is a hotly debated topic.

    • The term chromosomes refer to the replication and distribution of so much DNA are manageable because the DNA molecules are packaged into structures, (from the Greek chroma, color, and soma, body), so named because they take up certain dyes used in microscopy.

  • The consequences of abnormal cell activity in the body can be disastrous. The issue starts when a single cell in a tissue experiences the first of several stages that transforms a normal cell into a cancer cell.

  • This type of cell frequently has changed proteins on its surface, and the body's immune system typically detects it as a "nonself"—an insurgent—and eliminates it.

    Breast Cancer Cell

  • If the cell is not destroyed, it may grow and become a tumor, which is a mass of aberrant cells within otherwise normal tissue.

  • If the aberrant cells have too few genetic and cellular alterations to thrive at another location, they may stay in the original site. In that situation, the growth is referred to as a benign tumor.

  • Most benign tumors are not dangerous (depending on their location) and can be removed surgically. A malignant tumor, on the other hand, consists of cells that have undergone genetic and cellular changes that allow them to spread to new tissues and impair the functions of one or more organs; these cells are also sometimes referred to as transformed cells (though usage of this term is generally restricted to cells in culture), as shown in the image attached.

    • The term Cancer refers to being defined as an individual who has a malignant tumor.

  • Aside from excessive proliferation, the alterations that have happened in malignant tumor cells can be seen in a variety of ways.

  • These cells may contain an unusual number of chromosomes, however, whether this is a result of tumor-related alterations is debatable.

  • Their metabolism may be changed, and they may cease to operate in any useful manner. Cancer cells lose their attachments to surrounding cells and the extracellular matrix as a result of abnormal alterations on the cell surface, allowing them to move into neighboring tissues.

  • Cancer cells may also release signaling chemicals that stimulate the growth of blood arteries toward the tumor.

  • A few tumor cells may break out from the primary tumor, penetrate blood arteries and lymph vessels, and spread to distant regions of the body. They may multiply and create a new tumor there, as shown in the image attached above.

  • Metastasis refers to the spread of cancer cells to places other than their initial site. A confined tumor may be treated using high-energy radiation, which destroys DNA in cancer cells far more than DNA in normal cells, perhaps because the majority of cancer cells have lost the ability to repair such damage.

  • Chemotherapy is used to treat known or suspected metastatic cancers, in which medicines that are harmful to actively proliferating cells are given through the circulatory system.

  • Taxol, for example, blocks the mitotic spindle by inhibiting microtubule depolymerization, stopping actively dividing cells from progressing through metaphase and ultimately leading to their death.

  • Chemotherapy side effects are caused by the medicines' impact on normal cells, which divide regularly owing to the role of that cell type in the organism.