Parkinson's disease
- a movement disorder characterized by muscle tremors, rigidity, slow movements, and difficulty initiating physical and mental activity
- associated with an impairment in initiating spontaneous movement in the absence of stimuli to guide the action
- caused by gradual and progressive death of neurons, especially in the substantia nigra
- loss of dopamine leads to less stimulation of the motor cortex and slower onset of movements
- symptoms also include depression, memory and reasoning deficits, loss of olfaction, and other cognitive deficits