Chapter 9 Review - MusculoSkeletal Drugs

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Drugs used to treat osteoarthritis reduce pain and inflammation by inhibiting the production of…
NSAIDs (nonsteroidal anti-inflammatory drugs) are...
Are less likely than aspirin to cause gastric irritation or ulcers
The hormone cortisol, from which corticosteroid drugs are produced, is secreted by…
The cortex of the adrenal gland
Because of the side effects associated with their prolonged oral use, ________ are only prescribed to treat the acute symptoms of osteoarthritis for a limited time.
Corticosteroid drugs
The normal balance (homeostasis) between new bone deposition and bone resorption (breakdown) is maintained by all of the following, EXCEPT...
Exercise and exposure to the sun Parathyroid hormone and calcitonin hormone Calcium and vitamin D in the diet
Rheumatoid arthritis is…
an autoimmune response of the body's own immune system
What drug has the most powerful anti-inflammatory effect?
Hydrocortisone (Cortef)
Which of the following statements is TRUE concerning acetaminophen?
It is used to treat osteoarthritis.
All of the following are skeletal muscle relaxant drugs EXCEPT
Alendronate (Fosamax)
The long-term use of hormone replacement therapy to treat menopause and the symptoms of osteoporosis carries with it the risk of ________.
Myocardial Infarctio, Stroke, Breast & Endometrial cancer
Ibuprofen belongs to what category of drugs?
William Ruckles has severe rheumatoid arthritis. His physician prescribed ________an oral gold compound drug
Auranofin (Ridaura)
Rheumatoid arthritis is treated with
Gold compound drugs
The ending -profen is common to generic...
Nonsteroidal anti-inflammatory drugs
Risk factors for osteoporosis include all of the following EXCEPT
Weightbearing and constant movement of joints
Which of the following drugs is injected into a joint?
Betamethasone (Celestone) Triamcinolone (Aristospan Intra-articular) Hyaluronic acid (Hyalgan, Synvisc)
Which of the following statements about hyaluronic acid (Hyalgan Synvisc) is TRUE?
It is also used as a gel-type filler that is injected under the skin to minimize wrinkles.
All of the following are topical drugs used to treat the pain of osteoarthritis EXCEPT
Osteoporosis is treated with all of the following types of drugs EXCEPT
The therapeutic effect of etanercept (Enbrel) in treating rheumatoid arthritis is that it suppresses the immune response and blocks the...
Tumor necrosis factor
Bridget Maurer is taking a monoclonal antibody drug for her rheumatoid arthritis. That drug might include any of the following drugs EXCEPT
Abatacept (Orencia)
Which of these drugs is NOT used for synovial fluid replacement
Which bone resorption inhibitor drug must be given intravenously
Zoledronic acid (Reclast Zometa)
All of the following drugs are used to treat osteoarthritis EXCEPT
Muscle relaxant drugs
All of the following are the trade names of nonsteroidal anti-inflammatory drugs EXCEPT
Skelexin and Flexeril
Muscle relaxant drugs specifically relieve muscle
Spasms and stiffness
Which of the following drugs is used to treat fibromyalgia?
The anticonvulsant drug pregabalin (Lyrica) The antidepressant drug duloxetine (Cymbalta) The local anesthetic drug lidocaine (Xylocaine) injected into trigger points
________ drugs come in a special arrangement of oral tablets whose number continually decreases each day until the treatment is finished after one week
________ is also known as degenerative joint disease
Drugs used to treat osteoarthritis include those that reduce pain and inflammation. Which of the following categories of drugs do not reduce the pain and inflammation of osteoarthritis?
Gold compound drugs
Gold compound drugs...
Inhibit macrophages from the immune system Have names that often contain the letters RA
Only ________ drugs can reverse the cartilage and bone damage that has already occurred in the joints of patients with osteoarthritis
There are no drugs that can reverse the cartilage and bone damage of osteoarthritis once it has occurred.
The cause of fibromyalgia is...
Which joints are the first to exhibit signs of osteoarthritis.
All of them
The combining form oste/o- (as in osteoarthritis and osteoporosis) means...
All of these drugs are combination drugs used to treat osteoporosis. Which one is available as a transdermal patch?
Mature bone is a hard, unchanging substance
Some hormone replacement drugs used to treat menopause are also indicated for the prevention of osteoporosis.
Because acetaminophen has no anti-inflammatory action, it is no longer used to treat the pain associated with osteoarthritis.
NSAIDs are structurally similar enough to aspirin that some patients who are allergic to aspirin should not take NSAIDs.
Drugs that are derivatives of hyaluronic acid are injected into the joints of patients with osteoarthritis to improve the lubricating qualities of the synovial fluid.
The category of salicylate drugs used to treat osteoarthritis includes aspirin, one of the oldest drugs known to man.
Nonsteroidal anti-inflammatory drugs inhibit both the COX-1 and COX-2 enzymes.
Some corticosteroid drugs are given as intra-articular injections into a joint affected by osteoarthritis.
Two types of bone cells are constantly at work: Osteoclasts deposit new bone and osteoblasts break down and remove areas of old or damaged bone.
Calcitonin-salmon is the drug form of the body hormone calcitonin. This drug is derived from salmon fish
Muscle relaxant drugs are useful in treating the pain and inflammation of osteoarthritis of muscle strains, sprains, and "pulled muscles."
Chondroitin, a substance found in the dietary supplement Osteo Bi-Flex, helps cartilage retain its water content.
The topical drug capsaicin is a natural substance derived from chili pepper plants; it makes the skin and joint less sensitive to pain by decreasing nerve signals from sensory nerves.
Oral gold compound drugs can reverse joint damage that has already occurred in patients with rheumatoid arthritis.
Naproxen (Aleve, Naprosyn) belongs to the drug category of nonsteroidal anti-inflammatory drugs that are used to treat osteoarthritis.
The NSAID diclofenac (Voltaren) was the first prescription topical skin gel approved by the FDA for treating the pain of osteoarthritis.
The immunomodulator drug leflunomide (Arava), which is used to treat rheumatoid arthritis, is not given to patients with decreased liver function because it has a very long half-life.
The drug diazepam (Valium) is used for muscle relaxation, but it is really an antianxiety drug, not a skeletal muscle relaxant drug.
In women, parathyroid hormone, calcitonin hormone, calcium in the diet, vitamin D, exercise, and the hormones estradiol and progesterone help prevent rheumatoid arthritis.
Indomethacin (Indocin), a drug used to treat osteoarthritis, is also given intravenously to newborn infants to close a persistent patent ductus arteriosus heart defect, an abnormality in the fetal circulation.
The drug ibandronate (Boniva) has a unique bone-shaped indentation on its tablet.
Two COX-2 inhibitor drugs were taken off the market because of an increased risk of heart attacks and strokes. Only one COX-2 inhibitor is currently on the market.
The joints have a large number of pain receptors, and damage to the joints can cause chronic, severe pain.
Janus kinase (JAK) inhibitor drugs are used to treat fibromyalgia.
False (These drugs are used to treat rheumatoid arthritis)
The endings -dronate and -dronic are common to generic bone resorption inhibitor drugs that are used to treat osteoporosis.
The bone resorption inhibitor drug ibandronate (Boniva) is advertised as the osteoporosis drug that is easiest to remember to take because it is taken just once a month.
Monoclonal Antibody Drug
Golimumab (Simponi)
Bone Resorption Inhibitor Drug
Ibandronate (Boniva)
Gold Compound Drug
Auranofin (Ridaura)
Muscle Relaxant Drug
Cyclobenzaprine (Flexeril)
Salicylate Drug
Magnesium sulfate (Doan's)
Corticosteroid Drug
Methylprednisolone (Medrol)
Nonsteroidal Anti-Inflammatory Drug
Ibuprofen (Advil, Motrin)
Raloxifene (Evista)
COX-2 Inhibitor Drug
Celecoxib (Celebrex)
Estrogen Drug
Estropipate (Ogen)