Glycogenesis

Where does glycogenesis occur?

Liver, muscles

Step 1 of glycogenesis

Glucose + ATP -> Glucose 6 phosphate + ADP

Step 2 of glycogenesis

Glucose 6 phosphate -> glucose 1 phosphate

Step 3 of glycogenesis

Glucose 1-P + UTP → UDP-Glucose + PP

Step 3 of glycogenesis What is the enzyme?

UDP-Glucose + Glycogen (n) → Glycogen (n+1) + UDP Enzyme: Glycogen synthase

Hormonal regulation of glycogen synthesis

Favour glycogen synthesis 1. Insulin - activates PP1 and inhibits GSK-3 2. PP1 - activates glycogen synthase 3. Glucose activates PP1 Favour glycogen breakdown 1) PKA -> activates inhibitor 1 -> inhibits PP1 -> inhibits glycogen phosphorylase 2) Phosphorylase kinase inhibits glycogen synthase 3) Glycogen synthase kinase 3 (GSK-3) inhibits glycogen synthase

What is glycogen synthase inhibited by?

1) PKA 2) Phosphorylase kinase 3) Glycogen synthase kinase 3 (GSK-3)

What