Medicinal Plants

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Salicylic acid

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1

Salicylic acid

________ (SA) was synthesized in labs in Germany to treat gout and rheumatism.

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2

Ergotamine

the fungal basis for LSD

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3

migraine treatments, stopping post-partum bleeding

Clinical uses of the ergot alkaloids

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4

Tropane Alkaloids

What group relaxes the smooth muscle, dilates the pupil, dilates blood vessels, and stimulates the CNS?

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5

Dropsy

________ is a condition characterized by severe bloating due to fluid accumulation.

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6

Aspirin

________ irreversibly inhibits COX activity which is how it decreases inflammation, pain, and fever.

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7

Artemisia Annus

________ contains Artemisinin which is a sesquiterpenoid lactone, with an endo-peroxide bridge.

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8

Prostaglandin synthase

________ has 2 different catalytic activities, one is cyclooxygenase (COX) activity.

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9

European Yew

The ________ had a compound that contained the complicated ring structure in the needles.

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10

VCR

________ is more biologically active but found in smaller quantities.

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11

Quinine and chloroquine

________ both block the life cycle of the Plasmodium at the red blood cell stage.

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12

Acetyl Salicylic acid

________ is what aspirin actually is.

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13

Taxol

________ is particularly effective against solid tumors.

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14

Digitoxin

________ is the prescription drug made from digitalis.

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15

Ephedra

________ is the source of the alkaloid ephedrine.

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16

Arachidonate acid

________ (the precursor of prostaglandins) is synthesized in mammals from linoleic acid (18: 2)

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17

Plasmodium

________ is transmitted from person to person by a mosquito vector.

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18

Taxol

________ promoted the polymerization of microtubules but prevents depolymerization (so no daughter cells are formed)

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19

Prostaglandin

considered to be a "local hormone," stimulates inflammation, regulates blood flow

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20

Cinchona

The tree that contains quinine for the treatment of malaria

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21

Vinblastine

used in combination with other drugs to treat generalized Hodgkin's disease, and various lymphomas

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22

Vincristine

used to treat acute lymphocytic diseases, and used in combination with other drugs to treat Hodgkins disease, lymphosarcoma, etc

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23

St. Johns Wort

used for treating mild depression, (mood enhancer)

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24

Echinacea

used for "healthy immune function"

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25

VLB, VCR

________ has a methyl group (CH3) while _____ has an aldehyde group (CHO) instead.

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26

Vinblastine, Vincristine

In the plant, ________ is probably formed first and ________ is formed later as an oxidized product.

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27

Aspirin

________ doesn't occur naturally.

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28

25%

In the US, ____ of all prescription drugs are from plants or are based on plant-derived compounds

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29

Phenolic

Aspirin and related NSAIDs contain what type of group?

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30

Salicin

What compound is found in white willow bark?

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31

Analgesic, antipyretic, and anti-inflammatory

Aspirin is a

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32

it blocks the biosynthesis of prostagandins

Aspirin can reduce pain, fever and inflammation because

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33

NSAIDs

What types of drugs are based on the structure of aspirin?

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34

Alkaloid

Quinine is a

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35

chloroquine

________ is the main synthetic form of quinine

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36

dropsy

The leaves of Digitalis were shown more than 200 years ago to be very effective for treating

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37

by blocking the replication of Plasmodium in RBCs

Chloroquine has been used as a treatment for malaria since the 1940s, and acts

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38

Catharanthus, taxus

What plants can be used to treat cancer?

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39

Vinblastine and Vincristine

What are the two main alkaloids of the rosy periwinkle?

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40

Leukemia and cancers of the lymphatics

The Vinca Alkaloids are used to treat

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41

Pacific Yew BARK

Where is taxol found?

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42

Terpenoid

Taxol is a

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43

ovarian and breast cancers

Compounds for the Pacific Yew are used to treat

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44

Less restrictive growing range, needles are a renewable source, only semi-synthesis is needed

Advantages of using the European Yew

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45

They are not government regulated

Why can dietary supplements be dangerous?

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