Manufacturing (SAS 5)

the spontaneous passage of poorly water soluble solute into an aqueous solution of a soap or detergent, in which a thermodynamically stable solution is formed

the increase in solubility in water of various substances due to the presence of large amount of additives

substances which prevent bacterial and fungal growth in liquid

examples are alkyl esters of p-hydroxyl benzoic acid, benzoic acid, and its salts. In external use, boric acid and phenols are used

examples are chlorobutanol, benzyl alcohol, and phenylethyl alcohol

examples are themerosal, phenyl mercuric acetate or Nitrate

examples are benzalkonium chloride and cetyl pyridinium chloride

can be obtained in highly purified form

an extremely viscous substance which imparts both body and sweetness to liquid formulations

produce the desired sweetness at much lower concentration than sucrose

a unit operation in which a mixture of liquid and solids, slurry or feed is forced through a porous medium

woven from synthetic fiber, natural fiber, or metal

used to strain simple syrup or syrup preparations

often superior for pharmaceutical use since it is unaffected by molds, fungus or bacteria

a fibrous mass free from bonding agents

made by binding textile fabrics with resins

offers controlled porosity, limited absorption capacity, and a low cost

the basic tools for microfiltration and are used particularly in preparation of sterile solutions

acts by forming a highly porous and non-compressible cake which retains solids

limited to very large containers or to highly viscous products

accomplished by pumping of a liquid at a constant pressure

uses the container as the means of controlling the fill amount of each unit

any work, name, symbol of device placed on his goods to distinguish them from others

are easily wet by water or other polar liquids and may also greatly increase the viscosity of aqueous suspension

repels water but can easily be wet by non-polar liquids and do not alter the viscosity of aqueous suspension

the dispersing agent used should lower interfacial tension

produces finely divided particles by spraying mist of the liquid through a heated chamber

the rapid formation of aggregates of emulsion droplets

the result of the interaction of relatively weak particle which may have sufficient emulsifier coverage

the separation of emulsified droplets from the continuous phase

the percentage weight of the hydrophilic group divided by 5 for non-ionic emulsifiers

act by displacing the surface film with a film that resists foaming

provide the greatest ease of swallowing with the least tendency for hang up above the stomach

a solid dosage form containing medicinal substance with or without suitable diluents prepared by various molding technique or by fusion

recommended to speed up disintegration by breaking up starting from the mouth and for those who have difficulty in swallowing

those which contain drugs to be absorbed through the oral mucosa

placed beneath the tongue

placed at the side of the cheek or between the lip gum

consist of small tablets of compressed drug without excipients and are inserted into the body tissues by surgical procedure

multi-layered tablets which are made by the compression of several different granulations fed into a die in a succession

those that are employed to produce CO2 by chemical reaction of the component upon the addition of water

the granules are tableted while still damp and citric acid acts as a lubricant

is done by blending all components with the inclusion of 15-25% citric acid monohydrate

prepared by mixing the powders and then moistened with an alcohol-aqueous solution

the coating consists of a mixture of acute and the drug substance coaled unto small inert beads made up of a combination of sugar and starch

the drug is granulated with an inert plastic material and the granulation is compressed into tablets

for storing the material for compression

for distributing material into the dies

for controlling size and shape of tablets

for compacting the material within the dies

for guiding and punches

necessary for the transport of the material through the hopper into the feed frame

the property of forming a stable compact mass when pressure is applied

most often used diluent because it is inexpensive, stable, does not react with most medicinal substances, and has rapid solubility in the water

from wheat, corn, rice, and potato used as bulking agents, as binders and disintegrants

sometimes added to provide additional sweeteners but its main use is as a binder due to its cohesive property

a sugar obtained in a powder or granular form with no bound water and is used in chewable tablets

the trade name for microcrystalline

the trade name for hydrolyzed starch with dextrose

substances that glue powders together and cause them to form granules

added to compressed tablets to cause them to break apart or disintegrate when placed in an aqueous medium

it improves rate of flow of the granulation and prevent adhesion of the tablet material to the surface of the dies and punches

added to tablets for anesthetic value and to provide control during manufacture and distinguish one product from another

are dyes absorbed on Al (OH) and are insoluble in water

is used to accentuate fruit flavors and unmask aftertaste because of the sweet taste

has been used when the active ingredients are sensitive to heat, moisture, or both

it consists of 2 rollers controlled by hydraule grams

are compressed tablets coated with a thin layer of water-soluble polymeric substance capable of forming film over the tablet

the partial or complete separation of the top or bottom of a tablet from the main body

the separation of a tablet into 2 or more distant layers

the removal of edges of tablets

the removal of material from the surface of the tablet and its adherence to the face of the punch

the adhesion of granulation to the die wall

the unequal distribution of color on the surface of the tablet

measures the applied force in kg required to break a tablet

consists of a barrel containing a compressible spring held between two plungers

has the breaking force applied by a ham fastened to one end to a pivot

operates with the same principle as pliers with the tablets crushed in the jaws of the device, and the force is indicated on a dial indicator

the length of time by which substance has dissolved in the media of 0.1 N HCl, buffer or water at 37 degrees Celsius

in which any residue of the tablet except the fragments of insoluble coating remaining on the screen is a soft mass having no firm core

one or more medicinal or inert substance are enclosed within a small shell container generally prepared from a suitable form of gelatin

a convenient method by which a company or product identification in formation can be placed upon each capsule

capsules to which a special treatment has been given in an attempt to retard solubility in some manner

a measure of the cohesive strength of the cross-linking that occurs between gelatin molecules and is proportional to the molecular weight of the gelatin